{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T20:10:52Z","timestamp":1772827852277,"version":"3.50.1"},"reference-count":15,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6113","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,12,14]]},"abstract":"<jats:p>A drug that improves production of dystrophin protein reduces disease severity in a mouse model of Duchenne muscular dystrophy.<\/jats:p>","DOI":"10.1126\/science.1233074","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T19:18:51Z","timestamp":1355426331000},"page":"1431-1432","source":"Crossref","is-referenced-by-count":3,"title":["A Genetic Intervention Stands a Skip Away from Clinical Tests"],"prefix":"10.1126","volume":"338","author":[{"given":"Jeffrey S.","family":"Chamberlain","sequence":"first","affiliation":[{"name":"Departments of Neurology, Medicine, and Biochemistry, School of Medicine, University of Washington, 1959 N.E. Pacific Street, Seattle, WA 98195-7720, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/323646a0","volume":"323","author":"Monaco A. P.","year":"1986","unstructured":"Monaco A. P., et al.., Nature 323, 646 (1986).","journal-title":"Nature"},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0140-6736(11)60756-3","volume":"378","author":"Cirak S.","year":"2011","unstructured":"Cirak S., et al.., Lancet 378, 595 (2011).","journal-title":"Lancet"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011367"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005054"},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/343180a0","volume":"343","author":"England S. B.","year":"1990","unstructured":"England S. B., et al.., Nature 343, 180 (1990).","journal-title":"Nature"},{"key":"e_1_3_1_7_2","first-page":"498","volume":"45","author":"Koenig M.","year":"1989","unstructured":"Koenig M., et al.., Am. J. Hum. Genet. 45, 498 (1989).","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_3_1_8_2","first-page":"54","volume":"49","author":"Beggs A. H.","year":"1991","unstructured":"Beggs A. H., et al.., Am. J. Hum. Genet. 49, 54 (1991).","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nm0302-253","volume":"8","author":"Harper S. Q.","year":"2002","unstructured":"Harper S. Q., et al.., Nat. Med. 8, 253 (2002).","journal-title":"Nat. Med."},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1750-1172-7-45","volume":"7","author":"Nicolas A.","year":"2012","unstructured":"Nicolas A., et al.., Orphanet J. Rare Dis. 7, 45 (2012).","journal-title":"Orphanet J. Rare Dis."},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","first-page":"21783","DOI":"10.1074\/jbc.274.31.21783","volume":"274","author":"Schmajuk G.","year":"1999","unstructured":"Schmajuk G., Sierakowska H., Kole R., J. Biol. Chem. 274, 21783 (1999).","journal-title":"J. Biol. Chem."},{"key":"e_1_3_1_12_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nm1345","volume":"12","author":"Alter J.","year":"2006","unstructured":"Alter J., et al.., Nat. Med. 12, 175 (2006).","journal-title":"Nat. Med."},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.nmd.2007.07.005","volume":"17","author":"Neri M.","year":"2007","unstructured":"Neri M., et al.., Neuromuscul. Disord. 17, 913 (2007).","journal-title":"Neuromuscul. Disord."},{"key":"e_1_3_1_14_2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/hmg\/4.8.1251","volume":"4","author":"Phelps S. F.","year":"1995","unstructured":"Phelps S. F., et al.., Hum. Mol. Genet. 4, 1251 (1995).","journal-title":"Hum. Mol. Genet."},{"key":"e_1_3_1_15_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/humu.20918","volume":"30","author":"Aartsma-Rus A.","year":"2009","unstructured":"Aartsma-Rus A., et al.., Hum. Mutat. 30, 293 (2009).","journal-title":"Hum. Mutat."},{"key":"e_1_3_1_16_2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/mus.880140603","volume":"14","author":"Bertorini T. E.","year":"1991","unstructured":"Bertorini T. E., et al.., Muscle Nerve 14, 503 (1991).","journal-title":"Muscle Nerve"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1233074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T15:22:31Z","timestamp":1704900151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1233074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,14]]},"references-count":15,"journal-issue":{"issue":"6113","published-print":{"date-parts":[[2012,12,14]]}},"alternative-id":["10.1126\/science.1233074"],"URL":"https:\/\/doi.org\/10.1126\/science.1233074","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,14]]}}}