{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:16:56Z","timestamp":1791771416025,"version":"4.3.4"},"reference-count":33,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6123","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>A Role for IFN-\u025b<\/jats:title>\n                  <jats:p>\n                    Type I interferons (IFNs) are critical cytokines involved in host defense against pathogens, particularly viruses. IFN-\u025b is an IFN-like gene encoded within the type I IFN locus in mice and humans whose function has not been characterized.\n                    <jats:bold>\n                      Fung\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6123\" page=\"1088\" related-article-type=\"in-this-issue\" vol=\"339\" xlink:href=\"10.1126\/science.1233321\">1088<\/jats:related-article>\n                    ) created mice with a genetic deletion in\n                    <jats:italic>Ifn<\/jats:italic>\n                    -\u025b and found that, like other type I IFNs, IFN-\u025b signals through the IFN-\u03b1 receptors 1 and 2. However, unlike these other cytokines, which are primarily expressed by immune cells and are induced upon immune cell triggering, IFN-\u025b was expressed exclusively by epithelial cells of the female reproductive tract in both mice and humans and its expression was hormonally regulated. IFN-\u025b\u2013deficient mice were more susceptible to infection with herpes simplex virus 2 and\n                    <jats:italic>Chlamydia muridarum<\/jats:italic>\n                    , two common sexually transmitted pathogens.\n                  <\/jats:p>","DOI":"10.1126\/science.1233321","type":"journal-article","created":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T15:46:33Z","timestamp":1362066393000},"page":"1088-1092","source":"Crossref","is-referenced-by-count":256,"title":["Interferon-\u03b5 Protects the Female Reproductive Tract from Viral and Bacterial Infection"],"prefix":"10.1126","volume":"339","author":[{"given":"Ka Yee","family":"Fung","sequence":"first","affiliation":[{"name":"Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh E.","family":"Mangan","sequence":"additional","affiliation":[{"name":"Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Cumming","sequence":"additional","affiliation":[{"name":"Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay C.","family":"Horvat","sequence":"additional","affiliation":[{"name":"Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle, Newcastle, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemma R.","family":"Mayall","sequence":"additional","affiliation":[{"name":"Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle, Newcastle, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian A.","family":"Stifter","sequence":"additional","affiliation":[{"name":"Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"De Weerd","sequence":"additional","affiliation":[{"name":"Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila C.","family":"Roisman","sequence":"additional","affiliation":[{"name":"Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia."},{"name":"Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Rossjohn","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Robinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, South Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Schjenken","sequence":"additional","affiliation":[{"name":"Robinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, South Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Parker","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia."},{"name":"Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"Gargett","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia."},{"name":"Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong P. T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Hansbro","sequence":"additional","affiliation":[{"name":"Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle, Newcastle, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Hertzog","sequence":"additional","affiliation":[{"name":"Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-1114"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1957.0048"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2004.03.003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.08.009"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00053-4"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R700006200"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/35099560"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.7.3565"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2690"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035654"},{"key":"e_1_3_2_12_2","unstructured":"L. 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