{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:35:28Z","timestamp":1790015728638,"version":"4.0.1"},"reference-count":29,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6131","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,4,26]]},"abstract":"<jats:title>Viruses and Congenital Disorders<\/jats:title>\n                  <jats:p>\n                    Mutations in genes involved in \u03b1-dystroglycan O-linked glycosylation result in posttranslation modifications associated with the congenital disease Walker-Warburg syndrome (WWS). This cellular modification is also required for efficient Lassa virus infection of cells.\n                    <jats:bold>\n                      Jae\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6131\" page=\"479\" related-article-type=\"in-this-issue\" vol=\"340\" xlink:href=\"10.1126\/science.1233675\">479<\/jats:related-article>\n                    , published online 21 March) screened for genes involved in O-glycosylation that affected Lassa virus infection and identified candidates involved in glycosylation. Individuals from different pedigrees exhibiting WWS had unique mutations among genes identified in the genetic screen. Thus, comprehensive forward genetic screens can be used to define the genetic architecture of a complex disease.\n                  <\/jats:p>","DOI":"10.1126\/science.1233675","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T22:11:06Z","timestamp":1363903866000},"page":"479-483","source":"Crossref","is-referenced-by-count":271,"title":["Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry"],"prefix":"10.1126","volume":"340","author":[{"given":"Lucas T.","family":"Jae","sequence":"first","affiliation":[{"name":"Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs","family":"Raaben","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, 77 Avenue Louis Pasteur, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moniek","family":"Riemersma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute for Genetic and Metabolic Disease, Radboud University Medical Centre, 6525 GA Nijmegen, Netherlands."},{"name":"Laboratory of Genetic, Endocrine and Metabolic Disease, Institute for Genetic and Metabolic Disease, Radboud University Medical Centre, 6525 GA Nijmegen, Netherlands."},{"name":"Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Post Office Box 9101, 6500 HB Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"van Beusekom","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Post Office Box 9101, 6500 HB Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A.","family":"Blomen","sequence":"additional","affiliation":[{"name":"Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Velds","sequence":"additional","affiliation":[{"name":"Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron. 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