{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:16:07Z","timestamp":1792451767954,"version":"4.5.0"},"reference-count":27,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6124","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,3,8]]},"abstract":"<jats:title>\n                    On the Origin of Tumor T\n                    <jats:sub>regs<\/jats:sub>\n                  <\/jats:title>\n                  <jats:p>\n                    The tumor microenvironment is often seeded with regulatory T cells (T\n                    <jats:sub>regs<\/jats:sub>\n                    ), which inhibit antitumor immunity. Using mice with genetically driven prostate cancer,\n                    <jats:bold>\n                      Malchow\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6124\" page=\"1219\" related-article-type=\"in-this-issue\" vol=\"339\" xlink:href=\"10.1126\/science.1233913\">1219<\/jats:related-article>\n                    ; see the Perspective by\n                    <jats:bold>Joshi and Jacks<\/jats:bold>\n                    ) found a population of T\n                    <jats:sub>regs<\/jats:sub>\n                    that were enriched in the prostate of tumor-bearing mice. Surprisingly, these cells were also present in female mice and were found to be specific, not for a tumor-specific antigen, but rather for an antigen normally expressed in the prostate. Prostate antigen\u2013specific T\n                    <jats:sub>regs<\/jats:sub>\n                    arose in the thymus and their selection was dependent on Aire, a protein that drives the expression of tissue-specific antigens in the thymus. Thus, T\n                    <jats:sub>regs<\/jats:sub>\n                    that seed tumors likely arise in the thymus, are not necessarily tumor-specific, and are recruited and\/or expand in an organ when a tumor arises.\n                  <\/jats:p>","DOI":"10.1126\/science.1233913","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T14:36:41Z","timestamp":1362667001000},"page":"1219-1224","source":"Crossref","is-referenced-by-count":318,"title":["Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells"],"prefix":"10.1126","volume":"339","author":[{"given":"Sven","family":"Malchow","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Leventhal","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Nishi","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin I.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladell P.","family":"Paner","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet S.","family":"Amit","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulho","family":"Kang","sequence":"additional","affiliation":[{"name":"Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna E.","family":"Geddes","sequence":"additional","affiliation":[{"name":"Department of Immunology, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Immunology, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas D.","family":"Socci","sequence":"additional","affiliation":[{"name":"Bioinformatics Core, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Savage","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141623"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101324"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3216"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.8.3439"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500296"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.01.016"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070822"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.7032"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1318"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081359"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","unstructured":"A. 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