{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:28:30Z","timestamp":1792225710594,"version":"4.4.0"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6129","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,4,12]]},"abstract":"<jats:title>INTERFER(ON)ing Persistence<\/jats:title>\n                  <jats:p>\n                    During persistent viral infections, a dysregulated immune response fails to control the infection.\n                    <jats:bold>\n                      Wilson\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6129\" page=\"202\" related-article-type=\"in-this-issue\" vol=\"340\" xlink:href=\"10.1126\/science.1235208\">202<\/jats:related-article>\n                    ) and\n                    <jats:bold>\n                      Teijaro\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6129\" page=\"207\" related-article-type=\"in-this-issue\" vol=\"340\" xlink:href=\"10.1126\/science.1235214\">207<\/jats:related-article>\n                    ; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6129\" page=\"155\" related-article-type=\"in-this-issue\" vol=\"340\" xlink:href=\"10.1126\/science.1237568\">Odorizzi and Wherry<\/jats:related-article>\n                    <\/jats:bold>\n                    ) show this occurs because type I interferons (IFN I), critical for early responses to viral infection, contribute to the altered immunity seen during persistent infection. Antibody blockade of IFN I signaling during chronic lymphocytic choriomeningitis virus (LCMV) in mice resulted in reduced viral titers at later stages of infection, reduced expression of inhibitory immune molecules and prevented the disruptions to secondary lymphoid organs typically observed during persistent infection with LCMV. Whether type I IFNs are also detrimental to persistent viral infection humans, such as HIV and hepatitis C virus, remains to be determined.\n                  <\/jats:p>","DOI":"10.1126\/science.1235208","type":"journal-article","created":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T14:05:45Z","timestamp":1365689145000},"page":"202-207","source":"Crossref","is-referenced-by-count":700,"title":["Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection"],"prefix":"10.1126","volume":"340","author":[{"given":"Elizabeth B.","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas H.","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Elsaesser","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Herskovitz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Deng","sequence":"additional","affiliation":[{"name":"Division of Pulmonary 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