{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T12:07:44Z","timestamp":1794485264397,"version":"4.9.1"},"reference-count":27,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6132","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,5,3]]},"abstract":"<jats:title>Dynamic Protection<\/jats:title>\n                  <jats:p>\n                    During an immune response, CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells are recruited to provide protection. Most cells differentiate into short-lived effectors that help to clear the pathogen, whereas others form long-lived memory cells to protect against reinfection.\n                    <jats:bold>\n                      Gerlach\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6132\" page=\"635\" related-article-type=\"in-this-issue\" vol=\"340\" xlink:href=\"10.1126\/science.1235487\">635<\/jats:related-article>\n                    , published online 14 March) and\n                    <jats:bold>\n                      Buchholz\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6132\" page=\"630\" related-article-type=\"in-this-issue\" vol=\"340\" xlink:href=\"10.1126\/science.1235454\">630<\/jats:related-article>\n                    , published online 14 March) used in vivo fate mapping of mouse T cells with a defined specificity during a bacterial infection to show that the dynamics of the single-cell response are not uniform. The response of a particular T cell population is the average of a small number of clones that expand greatly (\u201clarge clones\u201d) and many clones that only proliferate at low amounts (\u201csmall clones\u201d). The memory pool arises largely from small clones whereas effectors are primarily made up of large clones.\n                  <\/jats:p>","DOI":"10.1126\/science.1235454","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T06:11:07Z","timestamp":1363327867000},"page":"630-635","source":"Crossref","is-referenced-by-count":409,"title":["Disparate Individual Fates Compose Robust CD8\n                    <sup>+<\/sup>\n                    T Cell Immunity"],"prefix":"10.1126","volume":"340","author":[{"given":"Veit R.","family":"Buchholz","sequence":"first","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, Technische Universit\u00e4t M\u00fcnchen (TUM), Munich 81675, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Flossdorf","sequence":"additional","affiliation":[{"name":"Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany."},{"name":"BioQuant Center, University of Heidelberg, Heidelberg 69120, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Hensel","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, Technische Universit\u00e4t M\u00fcnchen (TUM), Munich 81675, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Kretschmer","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, Technische Universit\u00e4t M\u00fcnchen (TUM), Munich 81675, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Weissbrich","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, Technische Universit\u00e4t M\u00fcnchen (TUM), Munich 81675, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Gr\u00e4f","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, Technische Universit\u00e4t M\u00fcnchen (TUM), Munich 81675, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Admar","family":"Verschoor","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, Technische Universit\u00e4t M\u00fcnchen (TUM), Munich 81675, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schiemann","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, Technische Universit\u00e4t M\u00fcnchen (TUM), Munich 81675, Germany."},{"name":"Clinical Cooperation Groups \u201cAntigen-specific Immunotherapy\u201d and \u201cImmune-Monitoring,\u201d Helmholtz Center Munich (Neuherberg), TUM, Munich 81675, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"H\u00f6fer","sequence":"additional","affiliation":[{"name":"Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany."},{"name":"BioQuant Center, University of Heidelberg, Heidelberg 69120, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk H.","family":"Busch","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, Technische Universit\u00e4t M\u00fcnchen (TUM), Munich 81675, Germany."},{"name":"Clinical Cooperation Groups \u201cAntigen-specific Immunotherapy\u201d and \u201cImmune-Monitoring,\u201d Helmholtz Center Munich (Neuherberg), TUM, Munich 81675, Germany."},{"name":"Focus Group \u201cClinical Cell Processing and Purification,\u201d Institute for Advanced Study, TUM, Munich 81675, Germany."},{"name":"National Centre for Infection Research (DZIF), Munich 81675, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"F. 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