{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:31:58Z","timestamp":1791221518509,"version":"4.1.0"},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6132","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,5,3]]},"abstract":"Dynamic Protection<\/jats:title>\n \n During an immune response, CD8\n +<\/jats:sup>\n T cells are recruited to provide protection. Most cells differentiate into short-lived effectors that help to clear the pathogen, whereas others form long-lived memory cells to protect against reinfection.\n \n Gerlach\n et al.<\/jats:italic>\n <\/jats:bold>\n (p.\n 635<\/jats:related-article>\n , published online 14 March) and\n \n Buchholz\n et al.<\/jats:italic>\n <\/jats:bold>\n (p.\n 630<\/jats:related-article>\n , published online 14 March) used in vivo fate mapping of mouse T cells with a defined specificity during a bacterial infection to show that the dynamics of the single-cell response are not uniform. The response of a particular T cell population is the average of a small number of clones that expand greatly (\u201clarge clones\u201d) and many clones that only proliferate at low amounts (\u201csmall clones\u201d). The memory pool arises largely from small clones whereas effectors are primarily made up of large clones.\n <\/jats:p>","DOI":"10.1126\/science.1235487","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T06:11:07Z","timestamp":1363327867000},"page":"635-639","source":"Crossref","is-referenced-by-count":366,"title":["Heterogeneous Differentiation Patterns of Individual CD8\n +<\/sup>\n T Cells"],"prefix":"10.1126","volume":"340","author":[{"given":"Carmen","family":"Gerlach","sequence":"first","affiliation":[{"name":"Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan C.","family":"Rohr","sequence":"additional","affiliation":[{"name":"Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands."},{"name":"Centre of Chronic Immunodeficiency (CCI), University Medical Centre Freiburg and University of Freiburg, Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u00efla","family":"Peri\u00e9","sequence":"additional","affiliation":[{"name":"Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands."},{"name":"Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke","family":"van Rooij","sequence":"additional","affiliation":[{"name":"Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen W. J.","family":"van Heijst","sequence":"additional","affiliation":[{"name":"Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Velds","sequence":"additional","affiliation":[{"name":"Central Genomics Facility, Netherlands Cancer Institute, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"Urbanus","sequence":"additional","affiliation":[{"name":"Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalin H.","family":"Naik","sequence":"additional","affiliation":[{"name":"Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Division of Biological Stress Responses, Netherlands Cancer Institute, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost B.","family":"Beltman","sequence":"additional","affiliation":[{"name":"Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands."},{"name":"Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob J.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ton N. 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