{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:34:04Z","timestamp":1791272044671,"version":"4.1.0"},"reference-count":43,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6157","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,10,25]]},"abstract":"<jats:title>Bite Me!<\/jats:title>\n                  <jats:p>\n                    As unpleasant as it is, pain serves a purpose, to alert the body to potential damage. This protective function may explain why few predators have evolved resistance to the painful venoms used as a defense by their prey. The grasshopper mouse, however, is insensitive to one of the most painful stings in the animal kingdom\u2014that of the bark scorpion.\n                    <jats:bold>\n                      Rowe\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6157\" page=\"441\" related-article-type=\"in-this-issue\" vol=\"342\" xlink:href=\"10.1126\/science.1236451\">441<\/jats:related-article>\n                    ; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6157\" page=\"428\" related-article-type=\"in-this-issue\" vol=\"342\" xlink:href=\"10.1126\/science.1244375\">Lewin<\/jats:related-article>\n                    <\/jats:bold>\n                    ) now show that grasshopper mice use the toxins present in the scorpion venom to block voltage-gated pain transmission, temporarily reducing their sensitivity to nonvenom-induced pain. Thus, grasshopper mice use the scorpion's painful defense to their advantage and have evolved a mechanism that allows for reduction of pain sensitivity only when it is needed.\n                  <\/jats:p>","DOI":"10.1126\/science.1236451","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T17:36:10Z","timestamp":1382636170000},"page":"441-446","source":"Crossref","is-referenced-by-count":133,"title":["Voltage-Gated Sodium Channel in Grasshopper Mice Defends Against Bark Scorpion Toxin"],"prefix":"10.1126","volume":"342","author":[{"given":"Ashlee H.","family":"Rowe","sequence":"first","affiliation":[{"name":"Section of Neurobiology, The University of Texas at Austin, Austin, TX 78712, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Sam Houston State University, Huntsville, TX 77341, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore R.","family":"Cummins","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold H.","family":"Zakon","sequence":"additional","affiliation":[{"name":"Section of Neurobiology, The University of Texas at Austin, Austin, TX 78712, USA."},{"name":"Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA 02543, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05413"},{"key":"e_1_3_2_3_2","unstructured":"J. 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