{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:43:32Z","timestamp":1792597412443,"version":"4.5.0"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6140","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,6,28]]},"abstract":"<jats:title>Unreactive Death<\/jats:title>\n                  <jats:p>\n                    A controversial proposal that all bactericidal antibiotics kill by reactive oxygen species (ROS) and not by their primary cell target has recently attracted high-profile refutations. The ROS-death pathway implicated overstimulation of the electron transport in respiratory chains; a malfunction that leads to ROS releasing Fe from Fe-S clusters and causing cell death via Fenton chemistry.\n                    <jats:bold>\n                      Ezraty\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6140\" page=\"1583\" related-article-type=\"in-this-issue\" vol=\"340\" xlink:href=\"10.1126\/science.1238328\">1583<\/jats:related-article>\n                    ) show that electron transport chains and Fe-S clusters are key to killing by aminoglycoside antibiotics but not for the reasons envisioned in the ROS theory. Fe-S clusters are essential for killing because they mature the respiratory chains that produce the necessary proton motive force for the energized uptake of aminoglycosides. Consequently, iron chelators protect against aminoglycosides, not because they scavenge the iron from Fenton chemistry, but because they block aminoglycoside uptake.\n                  <\/jats:p>","DOI":"10.1126\/science.1238328","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T14:06:26Z","timestamp":1372341986000},"page":"1583-1587","source":"Crossref","is-referenced-by-count":259,"title":["Fe-S Cluster Biosynthesis Controls Uptake of Aminoglycosides in a ROS-Less Death Pathway"],"prefix":"10.1126","volume":"340","author":[{"given":"Benjamin","family":"Ezraty","sequence":"first","affiliation":[{"name":"Laboratoire de Chimie Bact\u00e9rienne, Aix-Marseille Universit\u00e9, CNRS, UMR 7283, Institut de Microbiologie de la M\u00e9diterran\u00e9e, 31 Chemin Joseph Aiguier, 13009 Marseille France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Vergnes","sequence":"additional","affiliation":[{"name":"Laboratoire de 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