{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:38:28Z","timestamp":1792546708357,"version":"4.5.0"},"reference-count":23,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6150","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,9,6]]},"abstract":"<jats:title>More Determined Sex<\/jats:title>\n                  <jats:p>\n                    Although several transcription factors participate in mammalian sex determination, the contribution from specific epigenetic regulation is just being revealed.\n                    <jats:bold>\n                      Kuroki\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6150\" page=\"1106\" related-article-type=\"in-this-issue\" vol=\"341\" xlink:href=\"10.1126\/science.1239864\">1106<\/jats:related-article>\n                    ) show that a JmjC domain\u2013containing protein, Jmjd1a, catalyzes H3K9 demethylation of the Y-linked sex-determining gene\n                    <jats:italic>Sry<\/jats:italic>\n                    in mice to enable its expression above the required threshold level. Ablation of Jmjd1a function results in mouse male-to-female sex reversal, hence not only revealing a mechanism of\n                    <jats:italic>Sry<\/jats:italic>\n                    regulation but also the pivotal role of epigenetic regulation in mammalian sex determination.\n                  <\/jats:p>","DOI":"10.1126\/science.1239864","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T14:06:33Z","timestamp":1378389993000},"page":"1106-1109","source":"Crossref","is-referenced-by-count":255,"title":["Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a"],"prefix":"10.1126","volume":"341","author":[{"given":"Shunsuke","family":"Kuroki","sequence":"first","affiliation":[{"name":"Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, 53 Shogoin, Kawara-cho, Sakyo-ku, Kyoto, 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