{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:08:34Z","timestamp":1791349714260,"version":"4.3.1"},"reference-count":44,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6142","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,7,12]]},"abstract":"<jats:title>Magnesium to the Rescue<\/jats:title>\n                  <jats:p>\n                    Individuals with X-linked immunodeficiency with Mg\n                    <jats:sup>2+<\/jats:sup>\n                    defect, Epstein-Barr virus (EBV) infection, and neoplasia (XMEN) disease are genetically deficient for expression of\n                    <jats:italic>MAGT1<\/jats:italic>\n                    , a magnesium transporter.\n                    <jats:bold>\n                      Chaigne-Delalande\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6142\" page=\"186\" related-article-type=\"in-this-issue\" vol=\"341\" xlink:href=\"10.1126\/science.1240094\">186<\/jats:related-article>\n                    ) sought to better understand why these individuals are chronically infected with EBV at high viral loads and are susceptible to the development of lymphomas. CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and natural killer cells, which help to keep EBV infection in check, exhibited reduced cytotoxicity owing to their lower expression of the cell surface receptor NKG2D, which triggers cytolysis upon ligation. Magnesium supplementation in vitro and also in two XMEN patients restored levels of free Mg\n                    <jats:sup>2+<\/jats:sup>\n                    , increased NKG2D expression, and resulted in reduced amounts of EBV\n                    <jats:sup>+<\/jats:sup>\n                    cells, suggesting that this may be an effective therapeutic approach for XMEN patients.\n                  <\/jats:p>","DOI":"10.1126\/science.1240094","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T14:05:49Z","timestamp":1373551549000},"page":"186-191","source":"Crossref","is-referenced-by-count":332,"title":["Mg\n                    <sup>2+<\/sup>\n                    Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D"],"prefix":"10.1126","volume":"341","author":[{"given":"Benjamin","family":"Chaigne-Delalande","sequence":"first","affiliation":[{"name":"Molecular Development of the Immune System Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Yen","family":"Li","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA."},{"name":"Biomedical Sciences Graduate Program, University of California\u2013San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine M.","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Cancer and Inflammation Program, Laboratory of Experimental Immunology, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall J.","family":"Lukacs","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Shatzer","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Biancalana","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Pittaluga","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen F.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Jancel","sequence":"additional","affiliation":[{"name":"Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack J.","family":"Bleesing","sequence":"additional","affiliation":[{"name":"Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, OH 45229, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, OH 45229, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taco W.","family":"Kuijpers","sequence":"additional","affiliation":[{"name":"Pediatric Hematology, Immunology and Infectious Diseases, Academic Medical Center, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim E.","family":"Nichols","sequence":"additional","affiliation":[{"name":"Division of Oncology The Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie L.","family":"Lucas","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Nagpal","sequence":"additional","affiliation":[{"name":"Respiratory and Immunology Division, Merck Research Laboratories, Boston, MA 021159, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Mehmet","sequence":"additional","affiliation":[{"name":"Respiratory and Immunology Division, Merck Research Laboratories, Boston, MA 021159, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen C.","family":"Su","sequence":"additional","affiliation":[{"name":"Immunological Diseases Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Cancer and Inflammation Program, Laboratory of Experimental Immunology, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulbu","family":"Uzel","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Lenardo","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"113","article-title":"Magnesium as a regulatory cation: Criteria and evaluation","volume":"6","author":"Grubbs R. D.","year":"1987","unstructured":"Grubbs R. D., Maguire M. E., Magnesium as a regulatory cation: Criteria and evaluation. Magnesium 6, 113\u2013127 (1987).3306178","journal-title":"Magnesium"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1684\/mrh.2011.0286"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10246"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908332106"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00124.2009"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430707"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032015"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.047"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-275909"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)00038-2"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.05.052"},{"key":"e_1_3_2_13_2","first-page":"118","article-title":"Expression and functional activity of the Na\/Mg exchanger, TRPM7 and MagT1 are changed to regulate Mg homeostasis and transport in rumen epithelial cells","volume":"21","author":"Schweigel M.","year":"2008","unstructured":"Schweigel M., Kolisek M., Nikolic Z., Kuzinski J., Expression and functional activity of the Na\/Mg exchanger, TRPM7 and MagT1 are changed to regulate Mg homeostasis and transport in rumen epithelial cells. Magnes. Res. 21, 118\u2013123 (2008).18705540","journal-title":"Magnes. Res."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00457.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/35095564"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/85321"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.02.016"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2006.03.005"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00333-3"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-005-8786-4"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-346825"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.07.005"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.12.031"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1351"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.9.3551"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.17.13072"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08442.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001187"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200011)30:11<3309::AID-IMMU3309>3.0.CO;2-3"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3359"},{"key":"e_1_3_2_31_2","first-page":"85","article-title":"Manipulation of NKG2D ligands by cytomegaloviruses: Impact on innate and adaptive immune response","volume":"2","author":"Slavuljica I.","year":"2011","unstructured":"Slavuljica I., Krmpoti\u0107 A., Jonji\u0107 S., Manipulation of NKG2D ligands by cytomegaloviruses: Impact on innate and adaptive immune response. Front. Immunol. 2, 85 (2011).22566874","journal-title":"Front. Immunol."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214088109"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-336321"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01777-06"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.14"},{"key":"e_1_3_2_36_2","first-page":"408","article-title":"NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: Role in the NK cell-mediated negative regulation of T cell responses","volume":"3","author":"Zingoni A.","year":"2012","unstructured":"Zingoni A., Ardolino M., Santoni A., Cerboni C., NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: Role in the NK cell-mediated negative regulation of T cell responses. Front. Immunol. 3, 408 (2012).23316196","journal-title":"Front. Immunol."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2011.613931"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.09.016"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01429.x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0039"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.10.979"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70023-9"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1053\/jcrc.2002.36759"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2000.111060"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-285452"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1240094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T10:40:38Z","timestamp":1704883238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1240094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,12]]},"references-count":44,"journal-issue":{"issue":"6142","published-print":{"date-parts":[[2013,7,12]]}},"alternative-id":["10.1126\/science.1240094"],"URL":"https:\/\/doi.org\/10.1126\/science.1240094","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718029555.793487435","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718029555.793480112","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,12]]}}}