{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:54:30Z","timestamp":1792036470360,"version":"4.4.0"},"reference-count":29,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6164","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,12,13]]},"abstract":"<jats:title>Eye to Eyeless<\/jats:title>\n                  <jats:p>\n                    To what extent does adaptation rely on de novo mutation, as opposed to preexisting variation? It has been proposed that heat shock protein 90 (HSP90) can act to maintain cryptic variation by correcting misfolded proteins, until the system is taxed under stress conditions. Focusing on the cavefish\n                    <jats:italic>Astyanax mexicanus<\/jats:italic>\n                    ,\n                    <jats:bold>\n                      Rohner\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6164\" page=\"1372\" related-article-type=\"in-this-issue\" vol=\"342\" xlink:href=\"10.1126\/science.1240276\">1372<\/jats:related-article>\n                    ) provide evidence that this mechanism contributed to morphological evolution in a natural setting where cryptic variation in eye size was masked by HSP90 in the ancestral river but revealed when the fish were reared and selected in caves.\n                  <\/jats:p>","DOI":"10.1126\/science.1240276","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T14:16:18Z","timestamp":1386857778000},"page":"1372-1375","source":"Crossref","is-referenced-by-count":362,"title":["Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish"],"prefix":"10.1126","volume":"342","author":[{"given":"Nicolas","family":"Rohner","sequence":"first","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan F.","family":"Jarosz","sequence":"additional","affiliation":[{"name":"The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna E.","family":"Kowalko","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Maryland, College Park, MD 20742, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Jeffery","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Maryland, College Park, MD 20742, USA."},{"name":"Marine Biological Laboratory, Woods Hole, MA 02543, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Borowsky","sequence":"additional","affiliation":[{"name":"Department of Biology, New York University, New York, NY 10003, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Lindquist","sequence":"additional","affiliation":[{"name":"The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA."},{"name":"Howard Hughes Medical Institute, Cambridge, MA 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