{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:03:35Z","timestamp":1792292615543,"version":"4.4.0"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6152","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,9,20]]},"abstract":"<jats:title>Amyloid Binding Partners<\/jats:title>\n          <jats:p>\n            Amyloid-\u03b2 (A\u03b2) is critical to the pathology of Alzheimer's disease (AD), but its role in normal physiology remains unclear.\n            <jats:bold>\n              Kim\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6152\" page=\"1399\" related-article-type=\"in-this-issue\" vol=\"341\" xlink:href=\"10.1126\/science.1242077\">1399<\/jats:related-article>\n            ; see the Perspective by\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6152\" page=\"1354\" related-article-type=\"in-this-issue\" vol=\"341\" xlink:href=\"10.1126\/science.1244166\">\n              <jats:bold>Benilova and De Strooper<\/jats:bold>\n            <\/jats:related-article>\n            ) found that murine-paired immunoglobulin-like receptor B (PirB) and its human ortholog, leukocyte immunoglobulin-like receptor B2 (LilrB2) both bound to oligomerized A\u03b2. Early in mouse development, ocular dominance plasticity was affected by interactions between oligomeric A\u03b2 and PirB. In hippocampal brain slices from a mouse model of AD, reductions in long-term potentiation induced by A\u03b2 required PirB. Furthermore, the memory defects characteristic of a mouse model of AD were dependent on function of PirB. Many binding partners for A\u03b2 have been identified, and so the extent to which these findings can be exploited therapeutically remains unclear.\n          <\/jats:p>","DOI":"10.1126\/science.1242077","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T19:22:00Z","timestamp":1379618520000},"page":"1399-1404","source":"Crossref","is-referenced-by-count":381,"title":["Human LilrB2 Is a \u03b2-Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer\u2019s Model"],"prefix":"10.1126","volume":"341","author":[{"given":"Taeho","family":"Kim","sequence":"first","affiliation":[{"name":"Departments of Biology and Neurobiology and Bio-X, James H. Clark Center, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George S.","family":"Vidal","sequence":"additional","affiliation":[{"name":"Departments of Biology and Neurobiology and Bio-X, James H. Clark Center, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Djurisic","sequence":"additional","affiliation":[{"name":"Departments of Biology and Neurobiology and Bio-X, James H. Clark Center, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"William","sequence":"additional","affiliation":[{"name":"Neuropathology Service, Massachusetts General Hospital, Charlestown, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Birnbaum","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, and Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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