{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:51:46Z","timestamp":1790628706597,"version":"4.1.0"},"reference-count":33,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6152","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,9,20]]},"abstract":"<jats:title>Extracellular Regulation<\/jats:title>\n          <jats:p>\n            During\n            <jats:italic>Caenorhabditis elegans<\/jats:italic>\n            development, the hermaphrodite-specific neurons (HSNs) migrate and then extend axons toward their functional targets. Posttranslational modification of heparan sulfate proteoglycans are important for HSN development, and so\n            <jats:bold>\n              Pedersen\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6152\" page=\"1404\" related-article-type=\"in-this-issue\" vol=\"341\" xlink:href=\"10.1126\/science.1242528\">1404<\/jats:related-article>\n            ) tested the effect of disrupting or reducing chondroitin and heparan sulfate synthesis during\n            <jats:italic>C. elegans<\/jats:italic>\n            development. The results suggest that proteoglycan biosynthesis is tightly regulated by a microRNA pathway to shape the cell surface glycosylation architecture required to direct neuronal migration.\n          <\/jats:p>","DOI":"10.1126\/science.1242528","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T19:22:00Z","timestamp":1379618520000},"page":"1404-1408","source":"Crossref","is-referenced-by-count":81,"title":["An Epidermal MicroRNA Regulates Neuronal Migration Through Control of the Cellular Glycosylation State"],"prefix":"10.1126","volume":"341","author":[{"given":"Mikael Egebjerg","family":"Pedersen","sequence":"first","affiliation":[{"name":"Biotech Research and Innovation Centre, University of Copenhagen, Ole Maal\u00f8es Vej 5, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goda","family":"Snieckute","sequence":"additional","affiliation":[{"name":"Biotech Research and Innovation Centre, University of Copenhagen, Ole Maal\u00f8es Vej 5, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kagias","sequence":"additional","affiliation":[{"name":"Biotech Research and Innovation Centre, University of Copenhagen, Ole Maal\u00f8es Vej 5, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Nehammer","sequence":"additional","affiliation":[{"name":"Biotech Research and Innovation Centre, University of Copenhagen, Ole Maal\u00f8es Vej 5, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinke A.B.","family":"Multhaupt","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Couchman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Pocock","sequence":"additional","affiliation":[{"name":"Biotech Research and Innovation Centre, University of Copenhagen, Ole Maal\u00f8es Vej 5, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100109-104126"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.22.010605.093433"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.337030"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00084-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.11.023"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/27932"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.11.005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.60.070191.002303"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0901-809"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01635"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.6.2267"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/336638a0"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1666"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401591102"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2152"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.3.968"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061593098"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01634"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-5-r54"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2012.12.007"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1675"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.009"},{"key":"e_1_3_2_24_2","first-page":"31","article-title":"Chondroitin sulphate proteoglycans in extracellular matrices: Sulphation specificity in relation to cellular differentiation","volume":"151","author":"Couchman J. 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