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Using unbiased proteomic and targeted biochemical approaches, as well as two independent methods of lentiviral short hairpin RNA\u2013mediated gene knockdown in primary CD4 T cells, we identify interferon-\u03b3\u2013inducible protein 16 (IFI16) as a host DNA sensor required for CD4 T cell death due to abortive HIV infection. These findings provide insights into a key host pathway that plays a central role in CD4 T cell depletion during disease progression to AIDS.<\/jats:p>","DOI":"10.1126\/science.1243640","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T01:56:30Z","timestamp":1387504590000},"page":"428-432","source":"Crossref","is-referenced-by-count":508,"title":["IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV"],"prefix":"10.1126","volume":"343","author":[{"given":"Kathryn M.","family":"Monroe","sequence":"first","affiliation":[{"name":"Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, CA 94158, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, CA 94158, 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