{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:13:27Z","timestamp":1792023207978,"version":"4.4.0"},"reference-count":15,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6165","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,12,20]]},"abstract":"<jats:title>More from mTOR<\/jats:title>\n                  <jats:p>\n                    Leigh syndrome is a rare, untreatable, inherited neurodegenerative disease in children that is caused by functional disruption of mitochondria, the cell's energy-producing organelles.\n                    <jats:bold>\n                      Johnson\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6165\" page=\"1524\" related-article-type=\"in-this-issue\" vol=\"342\" xlink:href=\"10.1126\/science.1244360\">1524<\/jats:related-article>\n                    , published online 14 November; see Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6165\" page=\"1453\" related-article-type=\"in-this-issue\" vol=\"342\" xlink:href=\"10.1126\/science.1248449\">Vafai and Mootha<\/jats:related-article>\n                    <\/jats:bold>\n                    ) show that rapamycin, a drug used clinically as an immunosuppressant and for treatment of certain cancers, delayed the onset and progression of neurological symptoms in a mouse model of Leigh syndrome and significantly extended survival of the animals. Rapamycin inhibits the so-called \u201cmTOR\u201d signaling pathway, which is currently under intense study because it plays a contributory role in many common diseases.\n                  <\/jats:p>","DOI":"10.1126\/science.1244360","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T23:12:17Z","timestamp":1384470737000},"page":"1524-1528","source":"Crossref","is-referenced-by-count":512,"title":["mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome"],"prefix":"10.1126","volume":"342","author":[{"given":"Simon C.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melana E.","family":"Yanos","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington, Seattle, WA 98195, USA."},{"name":"Department of Psychology, University of 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S.","family":"Rabinovitch","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Anesthesiology and Pain Medicine, Seattle Children\u2019s Hospital, Seattle, WA 98105, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Sedensky","sequence":"additional","affiliation":[{"name":"Anesthesiology and Pain Medicine, Seattle Children\u2019s Hospital, Seattle, WA 98105, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Kaeberlein","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington, Seattle, WA 98195, 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