{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:07:20Z","timestamp":1790633240593,"version":"4.1.0"},"reference-count":24,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6165","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2013,12,20]]},"abstract":"<jats:title>Ubiquitin Fertility Insurance<\/jats:title>\n          <jats:p>\n            The female mammal's reproductive lifespan is determined by a pool of ovarian primordial follicles that are generated early in life.\n            <jats:bold>\n              Yu\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6165\" page=\"1518\" related-article-type=\"in-this-issue\" vol=\"342\" xlink:href=\"10.1126\/science.1244587\">1518<\/jats:related-article>\n            ) found that in mice, the ubiquitin E3 ligase complex CRL4 is essential for oocyte survival within primordial follicles and for development after fertilization. CRL4 binds to and activates an adaptor protein that mediates ubiquitination, but if any component is deleted, the genes required for oocyte maintenance and early embryo development are silenced and the female mice become infertile.\n          <\/jats:p>","DOI":"10.1126\/science.1244587","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T19:17:35Z","timestamp":1387480655000},"page":"1518-1521","source":"Crossref","is-referenced-by-count":106,"title":["CRL4 Complex Regulates Mammalian Oocyte Survival and Reprogramming by Activation of TET Proteins"],"prefix":"10.1126","volume":"342","author":[{"given":"Chao","family":"Yu","sequence":"first","affiliation":[{"name":"Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Life Sciences Institute and Innovation Center 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