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It is still largely unclear how tight this coupling is at mature synapses in the central nervous system.\n            <jats:bold>Vyleta and Jonas<\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6171\" page=\"665\" related-article-type=\"in-this-issue\" vol=\"343\" xlink:href=\"10.1126\/science.1244811\">665<\/jats:related-article>\n            ) found that mossy fiber boutons contain high concentrations of endogenous calcium buffers that normally limit the amount of calcium that reaches the calcium sensor responsible for neurotransmitter release. As a consequence, the calcium signal available to trigger release is small for the initial action potential. However, after high-frequency stimulation, the endogenous calcium buffer binds calcium and is less able to buffer calcium entry, which allows more calcium to reach the calcium sensor, increasing neurotransmitter release and synaptic facilitation.\n          <\/jats:p>","DOI":"10.1126\/science.1244811","type":"journal-article","created":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T19:20:12Z","timestamp":1391714412000},"page":"665-670","source":"Crossref","is-referenced-by-count":213,"title":["Loose Coupling Between Ca\n            <sup>2+<\/sup>\n            Channels and Release Sensors at a Plastic Hippocampal Synapse"],"prefix":"10.1126","volume":"343","author":[{"given":"Nicholas P.","family":"Vyleta","sequence":"first","affiliation":[{"name":"IST Austria (Institute of Science and Technology Austria), Am Campus 1, A-3400 Klosterneuburg, 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