{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:42:48Z","timestamp":1791211368173,"version":"4.1.0"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6173","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2014,2,21]]},"abstract":"<jats:title>Catalysis in the Membrane<\/jats:title>\n          <jats:p>\n            Enzymes in the UbiA superfamily of integral membrane proteins synthesize lipid-soluble aromatics such as ubiquinones and chlorophylls that function in energy storage and energy transfer in mitochondrial and chloroplast membranes.\n            <jats:bold>Cheng and Li<\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6173\" page=\"878\" related-article-type=\"in-this-issue\" vol=\"343\" xlink:href=\"10.1126\/science.1246774\">878<\/jats:related-article>\n            ) report structures of an archaeal UbiA protein in both apo and substrate-bound states. The structures show a large active site with a lateral portal that is likely to give access to the long-chain isoprenoid substrates. The findings suggest a mechanism for substrate recognition and catalysis and can explain disease-related mutants in eukaryotic homologs.\n          <\/jats:p>","DOI":"10.1126\/science.1246774","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T19:21:18Z","timestamp":1392924078000},"page":"878-881","source":"Crossref","is-referenced-by-count":153,"title":["Structural Insights into Ubiquinone Biosynthesis in Membranes"],"prefix":"10.1126","volume":"343","author":[{"given":"Wei","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040261"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09464"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027336"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.093112"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.01.013"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1218632"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.58.1814"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/S0021-9258(18)54102-8","article-title":"Biosynthesis of ubiquinone and plastoquinone in the endoplasmic reticulum-Golgi membranes of spinach leaves","volume":"268","author":"Swiezewska E.","year":"1993","unstructured":"Swiezewska E., Dallner G., Andersson B., Ernster L., Biosynthesis of ubiquinone and plastoquinone in the endoplasmic reticulum-Golgi membranes of spinach leaves. 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