{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:42:41Z","timestamp":1791333761883,"version":"4.3.1"},"reference-count":45,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6173","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2014,2,21]]},"abstract":"<jats:title>Two-Faced Viral Protein<\/jats:title>\n                  <jats:p>\n                    Flaviviruses cause human diseases such as West Nile fever and dengue fever. The flavivirus nonstructural protein 1 (NS1) has multiple functions in flavivirus biology and is a target for vaccine development. Dimeric NS1 is essential for replication of the viral genome inside host cells, while hexameric NS1 is secreted and plays a role in evasion of the immune system.\n                    <jats:bold>\n                      Akey\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6173\" page=\"881\" related-article-type=\"in-this-issue\" vol=\"343\" xlink:href=\"10.1126\/science.1247749\">881<\/jats:related-article>\n                    , published online 6 February; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6173\" page=\"849\" related-article-type=\"in-this-issue\" vol=\"343\" xlink:href=\"10.1126\/science.1251249\">Shi<\/jats:related-article>\n                    <\/jats:bold>\n                    ) report crystal structures for full-length glycosylated NS1 from West Nile and dengue viruses. The structures show a hexamer comprised of three dimers. The structural analysis together with liposome and mutational studies identify a membrane interacting surface on one face of the dimer and an immune evasion surface on the other.\n                  <\/jats:p>","DOI":"10.1126\/science.1247749","type":"journal-article","created":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T21:58:00Z","timestamp":1391723880000},"page":"881-885","source":"Crossref","is-referenced-by-count":416,"title":["Flavivirus NS1 Structures Reveal Surfaces for Associations with Membranes and the Immune System"],"prefix":"10.1126","volume":"343","author":[{"given":"David L.","family":"Akey","sequence":"first","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Clay","family":"Brown","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somnath","family":"Dutta","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Konwerski","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Jose","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Jurkiw","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"DelProposto","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig M.","family":"Ogata","sequence":"additional","affiliation":[{"name":"GM\/CA @ APS, Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Skiniotis","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA."},{"name":"Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, 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