{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:03:13Z","timestamp":1777366993763,"version":"3.51.4"},"reference-count":4,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6170","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2014,1,31]]},"abstract":"<jats:p>\n            The discovery of mutations associated with disease pathogenesis does not have to rest solely on genetic evidence.\n            <jats:named-content content-type=\"related-content\">\n              [Also see Research Article by\n              <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6170\" page=\"506\" related-article-type=\"in-this-issue\" vol=\"343\" xlink:href=\"10.1126\/science.1247363\">\n                Novarino\n                <jats:italic>et al.<\/jats:italic>\n              <\/jats:related-article>\n              ]\n            <\/jats:named-content>\n          <\/jats:p>","DOI":"10.1126\/science.1250172","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T20:36:18Z","timestamp":1391114178000},"page":"497-498","source":"Crossref","is-referenced-by-count":6,"title":["A Unified Process for Neurological Disease"],"prefix":"10.1126","volume":"343","author":[{"given":"Andrew B.","family":"Singleton","sequence":"first","affiliation":[{"name":"Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247363"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1115-8"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.04.018"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1250172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T20:37:48Z","timestamp":1704919068000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1250172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,31]]},"references-count":4,"journal-issue":{"issue":"6170","published-print":{"date-parts":[[2014,1,31]]}},"alternative-id":["10.1126\/science.1250172"],"URL":"https:\/\/doi.org\/10.1126\/science.1250172","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,31]]}}}