{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:52:05Z","timestamp":1792720325402,"version":"4.5.0"},"reference-count":46,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6204","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2014,9,26]]},"abstract":"<jats:title>A BLUEPRINT of immune cell development<\/jats:title>\n                  <jats:p>\n                    To determine the epigenetic mechanisms that direct blood cells to develop into the many components of our immune system, the BLUEPRINT consortium examined the regulation of DNA and RNA transcription to dissect the molecular traits that govern blood cell differentiation. By inducing immune responses, Saeed\n                    <jats:italic>et al.<\/jats:italic>\n                    document the epigenetic changes in the genome that underlie immune cell differentiation. Cheng\n                    <jats:italic>et al.<\/jats:italic>\n                    demonstrate that trained monocytes are highly dependent on the breakdown of sugars in the presence of oxygen, which allows cells to produce the energy needed to mount an immune response. Chen\n                    <jats:italic>et al.<\/jats:italic>\n                    examine RNA transcripts and find that specific cell lineages use RNA transcripts of different length and composition (isoforms) to form proteins. Together, the studies reveal how epigenetic effects can drive the development of blood cells involved in the immune system.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.1251086\">10.1126\/science.1251086<\/jats:related-article>\n                    ,\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.1250684\">10.1126\/science.1250684<\/jats:related-article>\n                    ,\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.1251033\">10.1126\/science.1251033<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.1250684","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T15:08:28Z","timestamp":1411657708000},"source":"Crossref","is-referenced-by-count":2150,"title":["mTOR- and HIF-1\u03b1\u2013mediated aerobic glycolysis as metabolic basis for trained immunity"],"prefix":"10.1126","volume":"345","author":[{"given":"Shih-Chin","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Quintin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Cramer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Shepardson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Faculties of Science and Medicine, Nijmegen Centre for Molecular Life Sciences, Radboud University, 6500 HB Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos J.","family":"Giamarellos-Bourboulis","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, University of Athens Medical School, 12462 Athens, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost H. A.","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Faculties of Science and Medicine, Nijmegen Centre for Molecular Life Sciences, Radboud University, 6500 HB Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagesha Appukudige","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Faculties of Science and Medicine, Nijmegen Centre for Molecular Life Sciences, Radboud University, 6500 HB Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Aghajanirefah","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Faculties of Science and Medicine, Nijmegen Centre for Molecular Life Sciences, Radboud University, 6500 HB Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh R.","family":"Manjeri","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculties of Science and Medicine, Nijmegen Centre for Molecular Life Sciences, Radboud University, 6500 HB Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela C.","family":"Ifrim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob J. 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