{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:42:00Z","timestamp":1792460520358,"version":"4.5.0"},"reference-count":43,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6203","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2014,9,19]]},"abstract":"<jats:title>Building connections by gene therapy<\/jats:title>\n                  <jats:p>\n                    Voluntary movement requires a molecular conversation between nerves and muscles. This conversation occurs at the neuromuscular junction, a structure where nerves and muscle physically connect. People with diseases characterized by muscle weakness have aberrantly small neuromuscular junctions. Arimura\n                    <jats:italic>et al.<\/jats:italic>\n                    used gene therapy to enlarge the neuromuscular junction, which made muscles stronger. Studying mouse models of two distinct neuromuscular disorders, they used an adenovirus vector to deliver\n                    <jats:italic>DOK7<\/jats:italic>\n                    , a gene required for formation of the neuromuscular junction. The therapy improved the mice's motor activity and life span.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6203\" page=\"1505\" related-article-type=\"in-this-issue\" vol=\"345\" xlink:href=\"10.1126\/science.1250744\">1505<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.1250744","type":"journal-article","created":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T14:14:53Z","timestamp":1411049693000},"page":"1505-1508","source":"Crossref","is-referenced-by-count":85,"title":["<i>DOK7<\/i>\n                    gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction"],"prefix":"10.1126","volume":"345","author":[{"given":"Sumimasa","family":"Arimura","sequence":"first","affiliation":[{"name":"Division of Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Tezuka","sequence":"additional","affiliation":[{"name":"Division of Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Chiyo","sequence":"additional","affiliation":[{"name":"Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 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