{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:46:12Z","timestamp":1793043972256,"version":"4.5.0"},"reference-count":62,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6179","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2014,4,4]]},"abstract":"<jats:title>Cyanide Hitches a Ride<\/jats:title>\n          <jats:p>\n            Cyanide is a by-product of the biosynthesis of ethylene in plants and it has been somewhat puzzling how the ion is safely removed before it can shut down enzymatic pathways by coordination to catalytic iron centers. A proposed mechanism has implicated the cyanoformate ion\u2014essentially, a weak adduct of cyanide and carbon dioxide\u2014as the initial product, although its lifetime was uncertain.\n            <jats:bold>\n              Murphy\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6179\" page=\"75\" related-article-type=\"in-this-issue\" vol=\"344\" xlink:href=\"10.1126\/science.1250808\">75<\/jats:related-article>\n            ; see the Perspective by\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6179\" page=\"45\" related-article-type=\"in-this-issue\" vol=\"344\" xlink:href=\"10.1126\/science.1252466\">\n              <jats:bold>Alabugin and Mohamed<\/jats:bold>\n            <\/jats:related-article>\n            ) crystallized this previously elusive adduct and found that its solution-phase stability varies inversely with the dielectric properties of the medium. The results bolster a picture in which the adduct shuttles the cyanide away from the hydrophobic confines of the enzyme before releasing the cyanide into the more polar aqueous surroundings.\n          <\/jats:p>","DOI":"10.1126\/science.1250808","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T18:34:18Z","timestamp":1396550058000},"page":"75-78","source":"Crossref","is-referenced-by-count":52,"title":["A Simple Complex on the Verge of Breakdown: Isolation of the Elusive Cyanoformate Ion"],"prefix":"10.1126","volume":"344","author":[{"given":"Luke J.","family":"Murphy","sequence":"first","affiliation":[{"name":"The Atlantic Centre for Green Chemistry, Department of Chemistry, Saint Mary\u2019s University, Halifax, Nova Scotia, B3H 3C3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine N.","family":"Robertson","sequence":"additional","affiliation":[{"name":"The Atlantic Centre for Green Chemistry, Department of Chemistry, Saint Mary\u2019s University, Halifax, Nova Scotia, B3H 3C3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott G.","family":"Harroun","sequence":"additional","affiliation":[{"name":"The Atlantic Centre for Green Chemistry, Department of Chemistry, Saint Mary\u2019s University, Halifax, Nova Scotia, B3H 3C3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa L.","family":"Brosseau","sequence":"additional","affiliation":[{"name":"The Atlantic Centre for Green Chemistry, Department of Chemistry, Saint Mary\u2019s University, Halifax, Nova Scotia, B3H 3C3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Werner-Zwanziger","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Institute for Research in Materials, Dalhousie University, Halifax, Nova Scotia, B3H 4J3, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jani","family":"Moilanen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, P.O. 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