{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:21:57Z","timestamp":1791350517060,"version":"4.3.1"},"reference-count":25,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6192","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2014,7,4]]},"abstract":"<jats:title>Exploiting nervous paths already traveled<\/jats:title>\n                  <jats:p>\n                    The parasympathetic nervous system helps regulate the functions of many tissues and organs, including the salivary glands and the esophagus. To do so, it needs to reach throughout the body, connecting central systems to peripheral ones. Dyachuk\n                    <jats:italic>et al.<\/jats:italic>\n                    and Espinosa-Medina\n                    <jats:italic>et al.<\/jats:italic>\n                    explored how these connections are established in mice (see the Perspective by Kalcheim and Rohrer). Progenitor cells that travel along with the developing nerves can give rise to both myelinforming Schwann cells and to parasympathetic neurons. That means the interacting nerves do not have to find each other. Instead, the beginnings of the connections are laid down as the nervous system develops.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6192\" page=\"82\" related-article-type=\"in-this-issue\" vol=\"345\" xlink:href=\"10.1126\/science.1253281\">82<\/jats:related-article>\n                    , p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6192\" page=\"87\" related-article-type=\"in-this-issue\" vol=\"345\" xlink:href=\"10.1126\/science.1253286\">87<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6192\" page=\"32\" related-article-type=\"in-this-issue\" vol=\"345\" xlink:href=\"10.1126\/science.1257175\">32<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.1253281","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T03:43:13Z","timestamp":1402630993000},"page":"82-87","source":"Crossref","is-referenced-by-count":220,"title":["Parasympathetic neurons originate from nerve-associated peripheral glial progenitors"],"prefix":"10.1126","volume":"345","author":[{"given":"Vyacheslav","family":"Dyachuk","sequence":"first","affiliation":[{"name":"Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden."},{"name":"A.V. Zhirmunsky Institute of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Furlan","sequence":"additional","affiliation":[{"name":"Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam Khatibi","family":"Shahidi","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Giovenco","sequence":"additional","affiliation":[{"name":"Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Kaukua","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysoula","family":"Konstantinidou","sequence":"additional","affiliation":[{"name":"Division of Molecular Neurobiology, Medical Research Council (MRC) National Institute for Medical Research, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Pachnis","sequence":"additional","affiliation":[{"name":"Division of Molecular Neurobiology, Medical Research Council (MRC) National Institute for Medical Research, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Memic","sequence":"additional","affiliation":[{"name":"Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrika","family":"Marklund","sequence":"additional","affiliation":[{"name":"Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Max Delbr\u00fcck Center for Molecular Medicine, Berlin-Buch, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Birchmeier","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Max Delbr\u00fcck Center for Molecular Medicine, Berlin-Buch, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Fried","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Ernfors","sequence":"additional","affiliation":[{"name":"Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Adameyko","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001660406"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2003.07.004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.22.4877"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.065581"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.07.049"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00161-1"},{"key":"e_1_3_2_8_2","first-page":"502","article-title":"Sox10 participates in the early development of neural crest by controlling its specification and survival","volume":"259","author":"Honore S. 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