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Splicing generates uninterrupted open reading frames that can be translated into proteins. Splicing is often highly regulated, generating alternative spliced forms that code for variant proteins in different tissues. RNA-binding proteins that bind specific sequences in the mRNA regulate splicing. Xiong\n                    <jats:italic>et al.<\/jats:italic>\n                    develop a computational model that predicts splicing regulation for any mRNA sequence (see the Perspective by Guig\u00f3 and Valc\u00e1rcel). They use this to analyze more than half a million mRNA splicing sequence variants in the human genome. They are able to identify thousands of known disease-causing mutations, as well as many new disease candidates, including 17 new autism-linked genes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.1254806\">10.1126\/science.1254806<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6218\" page=\"124\" related-article-type=\"in-this-issue\" vol=\"347\" xlink:href=\"10.1126\/science.aaa4864\">124<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.1254806","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T05:32:44Z","timestamp":1418967164000},"source":"Crossref","is-referenced-by-count":1154,"title":["The human splicing code reveals new insights into the genetic determinants of disease"],"prefix":"10.1126","volume":"347","author":[{"given":"Hui Y.","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada."},{"name":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada."},{"name":"Program on Genetic Networks and Program on Neural Computation &amp; Adaptive Perception, Canadian Institute for Advanced Research, Toronto, Ontario M5G 1Z8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Alipanahi","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada."},{"name":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada."},{"name":"Program on Genetic Networks and Program on Neural Computation &amp; Adaptive Perception, Canadian Institute for Advanced Research, Toronto, Ontario M5G 1Z8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada."},{"name":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada."},{"name":"Program on Genetic Networks and Program on Neural Computation &amp; Adaptive Perception, Canadian Institute for Advanced Research, Toronto, Ontario M5G 1Z8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Bretschneider","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada."},{"name":"Program on Genetic Networks and Program on Neural Computation &amp; Adaptive Perception, Canadian Institute for Advanced Research, Toronto, Ontario M5G 1Z8, Canada."},{"name":"Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Merico","sequence":"additional","affiliation":[{"name":"McLaughlin Centre, University of Toronto, Toronto, Ontario M5G 0A4, Canada."},{"name":"Centre for Applied Genomics, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada."},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan K. 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