{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:12:26Z","timestamp":1791249146976,"version":"4.1.0"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6203","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2014,9,19]]},"abstract":"<jats:title>Establishing memory of gene repression<\/jats:title>\n                  <jats:p>\n                    Although cells in the body contain the same DNA content, they can display widely varying form and function among tissues. This comes about by differential gene regulation and by establishing a type of gene expression memory that is passed down during cell division to daughter cells. Gaydos\n                    <jats:italic>et al.<\/jats:italic>\n                    report that in nematodes, both sperm and oocytes transmit a memory of chromatin repression to embryos in the form of modified histones. During DNA replication, modified histones are passed to daughter chromatids to provide chromatin memory for a few cell divisions. Histone-modifying enzymes replenish histone modifications and provide long-term chromatin memory.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6203\" page=\"1515\" related-article-type=\"in-this-issue\" vol=\"345\" xlink:href=\"10.1126\/science.1255023\">1515<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.1255023","type":"journal-article","created":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T14:14:53Z","timestamp":1411049693000},"page":"1515-1518","source":"Crossref","is-referenced-by-count":276,"title":["H3K27me and PRC2 transmit a memory of repression across generations and during development"],"prefix":"10.1126","volume":"345","author":[{"given":"Laura 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