{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T08:35:33Z","timestamp":1793522133402,"version":"4.5.0"},"reference-count":43,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6202","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2014,9,12]]},"abstract":"<jats:title>Evolution of Ebola virus over time<\/jats:title>\n                  <jats:p>\n                    The high rate of mortality in the current Ebola epidemic has made it difficult for researchers to collect samples of the virus and study its evolution. Gire\n                    <jats:italic>et al.<\/jats:italic>\n                    describe Ebola epidemiology on the basis of 99 whole-genome sequences, including samples from 78 affected individuals. The authors analyzed changes in the viral sequence and conclude that the current outbreak probably resulted from the spread of the virus from central Africa in the past decade. The outbreak started from a single transmission event from an unknown animal reservoir into the human population. Two viral lineages from Guinea then spread from person to person into Sierra Leone.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6202\" page=\"1369\" related-article-type=\"in-this-issue\" vol=\"345\" xlink:href=\"10.1126\/science.1259657\">1369<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.1259657","type":"journal-article","created":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T03:37:29Z","timestamp":1409283449000},"page":"1369-1372","source":"Crossref","is-referenced-by-count":1091,"title":["Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak"],"prefix":"10.1126","volume":"345","author":[{"given":"Stephen K.","family":"Gire","sequence":"first","affiliation":[{"name":"Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustine","family":"Goba","sequence":"additional","affiliation":[{"name":"Kenema Government Hospital, Kenema, Sierra Leone."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian G.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA."},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel S. 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