{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T04:35:07Z","timestamp":1792902907071,"version":"4.5.0"},"reference-count":36,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6220","license":[{"start":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T00:00:00Z","timestamp":1453507200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AI109023"],"award-info":[{"award-number":["R01 AI109023"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-13-BSV3-0018-01"],"award-info":[{"award-number":["ANR-13-BSV3-0018-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institut Pasteur, Division International","award":["ACIP A-10-2010"],"award-info":[{"award-number":["ACIP A-10-2010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2015,1,23]]},"abstract":"Mechanisms propelling drug resistance<\/jats:title>\n \n If it were to spread, resistance to the drug artemisinin would seriously derail the recent gains of global malaria control programs (see the Perspective by Sibley). Mutations in a region called the K13-propeller are predictive for artemisinin resistance in Southeast Asia. Mok\n et al.<\/jats:italic>\n looked at the patterns of gene expression in parasites isolated from more than 1000 patients sampled in Africa, Bangladesh, and the Mekong region. A range of mutations that alter protein repair pathways and the timing of the parasite's developmental cycle were only found in parasites from the Mekong region. Straimer\n et al.<\/jats:italic>\n genetically engineered the K13 region of parasites obtained from recent clinical isolates. Mutations in this region were indeed responsible for the resistance phenotypes.\n <\/jats:p>\n \n Science<\/jats:italic>\n , this issue p.\n 431<\/jats:related-article>\n , p.\n 428<\/jats:related-article>\n ; see also p.\n 373<\/jats:related-article>\n <\/jats:p>","DOI":"10.1126\/science.1260867","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:33:21Z","timestamp":1418344401000},"page":"428-431","source":"Crossref","is-referenced-by-count":692,"title":["K13-propeller mutations confer artemisinin resistance in\n Plasmodium falciparum<\/i>\n clinical isolates"],"prefix":"10.1126","volume":"347","author":[{"given":"Judith","family":"Straimer","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina F.","family":"Gn\u00e4dig","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Witkowski","sequence":"additional","affiliation":[{"name":"Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanaki","family":"Amaratunga","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine","family":"Duru","sequence":"additional","affiliation":[{"name":"Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arba Pramundita","family":"Ramadani","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie de Coordination UPR8241, Toulouse, France."},{"name":"Universit\u00e9 de Toulouse, UPS, Institut National Polytechnique de Toulouse, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Dacheux","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimol","family":"Khim","sequence":"additional","affiliation":[{"name":"Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sangamo BioSciences, Richmond, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lam","sequence":"additional","affiliation":[{"name":"Sangamo BioSciences, Richmond, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip D.","family":"Gregory","sequence":"additional","affiliation":[{"name":"Sangamo BioSciences, Richmond, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fyodor D.","family":"Urnov","sequence":"additional","affiliation":[{"name":"Sangamo BioSciences, Richmond, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Mercereau-Puijalon","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Parasite Molecular Immunology Unit, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Benoit-Vical","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie de Coordination UPR8241, Toulouse, France."},{"name":"Universit\u00e9 de Toulouse, UPS, Institut National Polytechnique de Toulouse, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick M.","family":"Fairhurst","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"M\u00e9nard","sequence":"additional","affiliation":[{"name":"Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Fidock","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY, USA."},{"name":"Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60424-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60024-0"},{"key":"e_1_3_2_4_2","first-page":"301","article-title":"Delaying antimalarial drug resistance with combination chemotherapy","volume":"41","author":"White N. J.","year":"1999","unstructured":"White N. J., Delaying antimalarial drug resistance with combination chemotherapy. Parassitologia 41, 301\u2013308 (1999).10697872","journal-title":"Parassitologia"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2239"},{"key":"e_1_3_2_6_2","unstructured":"World Health Organization World Malaria Report: 2013. WHO Press: Geneva Switzerland; available at www.who.int\/malaria\/publications\/world_malaria_report_2013\/en."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808859"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314981"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1403007"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00686-12"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70181-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-411"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70252-4"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12876"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1215966"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211205110"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2624"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(99)01673-6"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01636-09"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70777-7"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2143"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2925"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(82)90289-9"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03055-14"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu491"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105690"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu467"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2013.07.005"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.10.015"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt486"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1104063108"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006113108"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190710074"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2842"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06250.x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.54.6.1140"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-187401"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1260867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T15:53:08Z","timestamp":1704901988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1260867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,23]]},"references-count":36,"journal-issue":{"issue":"6220","published-print":{"date-parts":[[2015,1,23]]}},"alternative-id":["10.1126\/science.1260867"],"URL":"https:\/\/doi.org\/10.1126\/science.1260867","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725276211.793518968","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,23]]}}}