{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:01:42Z","timestamp":1791104502658,"version":"4.1.0"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5080","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1992,10,9]]},"abstract":"<jats:p>\n            Presynaptic calcium channels are crucial elements of neuronal excitation-secretion coupling. In mammalian brain, they have been difficult to characterize because most presynaptic terminals are too small to probe with electrodes, and available pharmacological tools such as dihydropyridines and \u03c9-conotoxin are largely ineffective. Subsecond measurements of synaptosomal glutamate release have now been used to assess presynaptic calcium channel activity in order to study the action of peptide toxins from the venom of the funnel web spider\n            <jats:italic>Agelenopsis aperta<\/jats:italic>\n            , which is known to inhibit dihydropyridine and \u03c9-conotoxin-resistant neuronal calcium currents. A presynaptic calcium channel important in glutamate release is shown to be \u03c9-Aga-IVA sensitive and \u03c9-conotoxin resistant.\n          <\/jats:p>","DOI":"10.1126\/science.1357749","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:03:06Z","timestamp":1160089386000},"page":"310-313","source":"Crossref","is-referenced-by-count":241,"title":["Calcium Channels Coupled to Glutamate Release Identified by \u03c9-Aga-IVA"],"prefix":"10.1126","volume":"258","author":[{"given":"Timothy J.","family":"Turner","sequence":"first","affiliation":[{"name":"Department of Physiology, Tufts University School of Medicine, Boston, MA 02111."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Adams","sequence":"additional","affiliation":[{"name":"Departments of Entomology and Neuroscience, University of California, Riverside, CA 92521."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Dunlap","sequence":"additional","affiliation":[{"name":"Department of Physiology, Tufts University School of Medicine, Boston, MA 02111."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1146\/annurev.ne.10.030187.003221","volume":"10","year":"1987","unstructured":"AUGUSTINE, G.J., CALCIUM ACTION IN SYNAPTIC TRANSMITTER RELEASE, ANNUAL REVIEW OF NEUROSCIENCE 10: 633 (1987).","journal-title":"ANNUAL REVIEW OF NEUROSCIENCE"},{"key":"e_1_2_1_2_1","first-page":"200","volume":"341","year":"1990","unstructured":"HOFMANN, F, ROLE OF OMEGA-CONOTOXIN-SENSITIVE CALCIUM CHANNELS IN INOSITOLPHOSPHATE PRODUCTION AND NORADRENALINE RELEASE DUE TO POTASSIUM DEPOLARIZATION OR STIMULATION WITH CARBACHOL, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 341: 200 (1990).","journal-title":"NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1111\/j.1476-5381.1991.tb09855.x","volume":"103","year":"1991","unstructured":"HORNE, A.L., THE EFFECT OF OMEGA-CONOTOXIN GVIA ON SYNAPTIC TRANSMISSION WITHIN THE NUCLEUS-ACCUMBENS AND HIPPOCAMPUS OF THE RAT INVITRO, BRITISH JOURNAL OF PHARMACOLOGY 103: 1733 (1991).","journal-title":"BRITISH JOURNAL OF PHARMACOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/308282a0","volume":"308","year":"1984","unstructured":"KERR, L.M., A VENOM PEPTIDE WITH A NOVEL PRESYNAPTIC BLOCKING ACTION, NATURE 308: 282 (1984).","journal-title":"NATURE"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/0896-6273(89)90187-6","volume":"2","year":"1989","unstructured":"LEMOS, J.R., 2 TYPES OF CALCIUM CHANNELS COEXIST IN PEPTIDE-RELEASING VERTEBRATE NERVE-TERMINALS, NEURON 2: 1419 (1989).","journal-title":"NEURON"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1113\/jphysiol.1989.sp017684","volume":"414","year":"1989","unstructured":"LINDGREN, C. 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