{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:46:55Z","timestamp":1791107215944,"version":"4.1.0"},"reference-count":16,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3533","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1962,9,14]]},"abstract":"<jats:p>A new approach to the important but difficult task of revealing possible human tumor viruses has been presented in this article. By systematic testing of already known human viruses for oncogenic properties, it was found that in hamsters injected intrapulmonarily with tissue culture fluid of human type 12 adenovirus within 24 hours after birth there was a very high incidence of malignant tumors at the site of injection in from 1 to 3 months. The tumor-inducing activity was not lost by filtration through Selas 02 filters or by tissue culture passages in HeLa cells. Tumors thus induced grew in, and killed, a high percentage of the unconditioned young adult hamsters into which they were transplanted. No such tumors occurred in hamsters injected with control tissue culture fluid or with culture fluids of the other viruses tested, or in control breeder hamsters. The possibility that contamination with polyoma virus and simian virus 40 might be responsible for the tumors induced was specifically excluded by a variety of tests. The possible involvement of still other, as yet unknown, contaminant viruses was excluded by a positive association of the tumor-inducing ability with the adenovirus content. Of eight human sera tested, only those four which neutralized the adenovirus-type cytopathic effect also neutralized the tumor-inducing effect. Of 700 human sera tested, 26 percent contained CPE-neutralizing antibodies for type 12 adenovirus at titers of 1:4 and higher.<\/jats:p>","DOI":"10.1126\/science.137.3533.835","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T08:58:10Z","timestamp":1160038690000},"page":"835-841","source":"Crossref","is-referenced-by-count":394,"title":["The Quest for Human Cancer Viruses"],"prefix":"10.1126","volume":"137","author":[{"given":"John J.","family":"Trentin","sequence":"first","affiliation":[{"name":"The division of experimental biology of Baylor University College of Medicine and with the section of experimental pediatrics, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Yabe","sequence":"additional","affiliation":[{"name":"The division of experimental biology of Baylor University College of Medicine and with the section of experimental pediatrics, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Taylor","sequence":"additional","affiliation":[{"name":"The division of experimental biology of Baylor University College of Medicine and with the section of experimental pediatrics, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"1123","volume":"23","year":"1959","unstructured":"BANFIELD, W.G., INTRACELLULAR AND EXTRACELLULAR PARTICLES IN TISSUE CULTURES INOCULATED WITH PAROTID-TUMOR AGENT (POLYOMA VIRUS), JOURNAL OF THE NATIONAL CANCER INSTITUTE 23: 1123 (1959).","journal-title":"JOURNAL OF THE NATIONAL CANCER INSTITUTE"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3181\/00379727-84-20636","volume":"84","year":"1953","unstructured":"BUNTING, H, CLOSE-PACKED ARRAY OF VIRUS-LIKE PARTICLES WITHIN CELLS OF A HUMAN SKIN PAPILLOMA, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 84: 327 (1953).","journal-title":"PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_3_1","first-page":"CH7","year":"1959","unstructured":"Duran-Reynals, F., The Physiopathology of Cancer: CH7 (1959).","journal-title":"The Physiopathology of Cancer"},{"key":"e_1_2_1_4_1","first-page":"747","volume":"20","year":"1958","unstructured":"EDDY, B.E., NEOPLASMS IN HAMSTERS INDUCED BY MOUSE TUMOR AGENT PASSED IN TISSUE CULTURE, JOURNAL OF THE NATIONAL CANCER INSTITUTE 20: 747 (1958).","journal-title":"JOURNAL OF THE NATIONAL CANCER INSTITUTE"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3181\/00379727-107-26576","volume":"107","year":"1961","unstructured":"EDDY, B.E., TUMORS INDUCED IN HAMSTERS BY INJECTION OF RHESUS MONKEY KIDNEY CELL EXTRACTS, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 107: 191 (1961).","journal-title":"PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0042-6822(62)90082-X","volume":"17","year":"1962","unstructured":"EDDY, B.E., IDENTIFICATION OF ONCOGENIC SUBSTANCE IN RHESUS MONKEY KIDNEY CELL CULTURES AS SIMIAN VIRUS 40, VIROLOGY 17: 65 (1962).","journal-title":"VIROLOGY"},{"key":"e_1_2_1_7_1","first-page":"611","volume":"94","year":"1957","unstructured":"FOLEY, G.E., PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 94: 611 (1957).","journal-title":"PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3181\/00379727-109-27298","volume":"109","year":"1962","unstructured":"GIRARDI, A.J., DEVELOPMENT OF TUMORS IN HAMSTERS INOCULATED IN NEONATAL PERIOD WITH VACUOLATING VIRUS, SV40, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 109: 649 (1962).","journal-title":"PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_9_1","first-page":"403","volume":"5","year":"1957","unstructured":"HILLEMAN, M.R., NEW YORK ACADEMY OF SCIENCES SPECIAL PUBLICATIONS 5: 403 (1957).","journal-title":"NEW YORK ACADEMY OF SCIENCES SPECIAL PUBLICATIONS"},{"key":"e_1_2_1_10_1","first-page":"393","volume":"5","year":"1957","unstructured":"HUEBNER, R.J., NEW YORK ACADEMY OF SCIENCES SPECIAL PUBLICATIONS 5: 393 (1957).","journal-title":"NEW YORK ACADEMY OF SCIENCES SPECIAL PUBLICATIONS"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1749-6632.1957.tb46055.x","volume":"67","year":"1957","unstructured":"KIBRICK, S, CLINICAL ASSOCIATIONS OF ENTERIC VIRUSES WITH PARTICULAR REFERENCE TO AGENTS EXHIBITING PROPERTIES OF THE ECHO GROUP, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 67: 311 (1957).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_12_1","first-page":"611","volume":"26","year":"1961","unstructured":"NERIISHI, S, EFFECTS IN NEWBORN MICE OF TUMOR-PRODUCING AGENTS CARRIED IN TISSUE CULTURE, JOURNAL OF THE NATIONAL CANCER INSTITUTE 26: 611 (1961).","journal-title":"JOURNAL OF THE NATIONAL CANCER INSTITUTE"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1128\/br.25.1.18-31.1961","volume":"25","year":"1961","unstructured":"ROWE, W.P., EPIDEMIOLOGY OF MOUSE POLYOMA VIRUS INFECTION, BACTERIOLOGICAL REVIEWS 25: 18 (1961).","journal-title":"BACTERIOLOGICAL REVIEWS"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1084\/jem.109.5.449","volume":"109","year":"1959","unstructured":"ROWE, W.P., STUDIES OF MOUSE POLYOMA VIRUS INFECTION .3. 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