{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:02:46Z","timestamp":1791187366761,"version":"4.1.0"},"reference-count":33,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5045","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1992,2,7]]},"abstract":"<jats:p>\n            L-Arginine causes insulin release from pancreatic B cells. Data from three model systems support the hypothesis that L-arginine-derived nitrogen oxides (NOs) mediate insulin release stimulated by L-arginine in the presence of D-glucose and by the hypoglycemic drug tolbutamide. The formation of NO in pancreatic B cells was detected both chemically and by the NO-induced accumulation of guanosine 3\u2032,5\u2032-monophosphate. N\n            <jats:sup>G<\/jats:sup>\n            -substituted L-arginine analogs inhibited the release of both insulin and NO. Protein immunoblot and histochemical analysis with antiserum to type I NO synthase suggest that the formation of NO in pancreatic B cells is catalyzed by an NADPH- (reduced form of nicotinamide adenine dinucleotide phosphate), Ca\n            <jats:sup>2+<\/jats:sup>\n            \/calmodulin-dependent type I NO synthase of about 150 kilodaltons.\n          <\/jats:p>","DOI":"10.1126\/science.1371193","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:03:06Z","timestamp":1160074986000},"page":"721-723","source":"Crossref","is-referenced-by-count":325,"title":["Insulin Secretion from Pancreatic B Cells Caused by L-Arginine-Derived Nitrogen Oxides"],"prefix":"10.1126","volume":"255","author":[{"given":"Harald H. H. W.","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Warner","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Shizuoka School of Pharmaceutical Sciences, 395 Yada, Shizuoaka-shi, Skizuoka-ken 422, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Sheng","sequence":"additional","affiliation":[{"name":"Abbott Laboratories, Abbott Park, IL 60064."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FeridF","family":"Murad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611."},{"name":"Abbott Laboratories, Abbott Park, IL 60064."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1042\/bst0161017","volume":"16","year":"1988","unstructured":"BJAALAND, T, ARGININE-INDUCED GLUCAGON-SECRETION FROM ELECTRICALLY PERMEABILIZED ISLETS OF LANGERHANS, BIOCHEMICAL SOCIETY TRANSACTIONS 16: 1017 (1988).","journal-title":"BIOCHEMICAL SOCIETY TRANSACTIONS"},{"key":"e_1_2_1_2_1","first-page":"A467","volume":"32","year":"1990","unstructured":"BJAALAND, T, DIABETOLOGIA 32: A467 (1990).","journal-title":"DIABETOLOGIA"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/351714a0","volume":"351","year":"1991","unstructured":"BREDT, D.S., CLONED AND EXPRESSED NITRIC-OXIDE SYNTHASE STRUCTURALLY RESEMBLES CYTOCHROME-P-450 REDUCTASE, NATURE 351: 714 (1991).","journal-title":"NATURE"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1172\/JCI105456","volume":"45","year":"1966","unstructured":"FLOYD, J.C., STIMULATION OF INSULIN SECRETION BY AMINO ACIDS, JOURNAL OF CLINICAL INVESTIGATION 45: 1487 (1966).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_5_1","first-page":"7","volume":"38","year":"1990","unstructured":"FORSTERMANN, U, HORMONE-INDUCED BIOSYNTHESIS OF ENDOTHELIUM-DERIVED RELAXING FACTOR NITRIC OXIDE-LIKE MATERIAL IN N1E-115 NEUROBLASTOMA-CELLS REQUIRES CALCIUM AND CALMODULIN, MOLECULAR PHARMACOLOGY 38: 7 (1990).","journal-title":"MOLECULAR PHARMACOLOGY"},{"key":"e_1_2_1_6_1","first-page":"1788","volume":"88","year":"1991","unstructured":"FORSTERMANN, U, CALMODULIN-DEPENDENT ENDOTHELIUM-DERIVED RELAXING FACTOR NITRIC-OXIDE SYNTHASE ACTIVITY IS PRESENT IN THE PARTICULATE AND CYTOSOLIC FRACTIONS OF BOVINE AORTIC ENDOTHELIAL-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 1788 (1991).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1042\/bj1920919","volume":"192","year":"1980","unstructured":"GAGLIARDINO, J.J., EVIDENCE FOR THE PARTICIPATION OF CALMODULIN IN STIMULUS-SECRETION COUPLING IN THE PANCREATIC BETHA-CELL, BIOCHEMICAL JOURNAL 192: 919 (1980).","journal-title":"BIOCHEMICAL JOURNAL"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.2337\/diab.33.6.516","volume":"33","year":"1984","unstructured":"GANDA, O.P., DIFFERENTIAL SENSITIVITY TO BETA-CELL SECRETAGOGUES IN EARLY, TYPE-I DIABETES-MELLITUS, DIABETES 33: 516 (1984).","journal-title":"DIABETES"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0006-291X(90)91245-N","volume":"170","year":"1990","unstructured":"GROSS, S.S., MACROPHAGE AND ENDOTHELIAL-CELL NITRIC-OXIDE SYNTHESIS - 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