{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:05:22Z","timestamp":1792148722785,"version":"4.4.0"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5056","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1992,4,24]]},"abstract":"<jats:p>\n            Blood pressure and tissue perfusion are controlled in part by the level of intrinsic (myogenic) vascular tone. However, many of the molecular determinants of this response are unknown. Evidence is now presented that the degree of myogenic tone is regulated in part by the activation of large-conductance calcium-activated potassium channels in arterial smooth muscle. Tetraethylammonium ion (TEA\n            <jats:sup>+<\/jats:sup>\n            ) and charybdotoxin (CTX), at concentrations that block calcium-activated potassium channels in smooth muscle cells isolated from cerebral arteries, depolarized and constricted pressurized cerebral arteries with myogenic tone. Both TEA+ and CTX had little effect on arteries when intracellular calcium was reduced by lowering intravascular pressure or by blocking calcium channels. Elevation of intravascular pressure through membrane depolarization and an increase in intracellular calcium may activate calcium-activated potassium channels. Thus, these channels may serve as a negative feedback pathway to control the degree of membrane depolarization and vasoconstriction.\n          <\/jats:p>","DOI":"10.1126\/science.1373909","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:03:06Z","timestamp":1160089386000},"page":"532-535","source":"Crossref","is-referenced-by-count":785,"title":["Regulation of Arterial Tone by Activation of Calcium-Dependent Potassium Channels"],"prefix":"10.1126","volume":"256","author":[{"given":"Joseph E.","family":"Brayden","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Vermont Center for Vascular Research, The University of Vermont, Medical Research Facility, Colchester, VT 05446"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Vermont Center for Vascular Research, The University of Vermont, Medical Research Facility, Colchester, VT 05446"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1113\/jphysiol.1982.sp014370","volume":"331","year":"1982","unstructured":"BARRETT, J. N., JOURNAL OF PHYSIOLOGY-LONDON 331: 211 (1982).","journal-title":"JOURNAL OF PHYSIOLOGY-LONDON"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1113\/jphysiol.1902.sp000911","volume":"28","year":"1902","unstructured":"BAYLISS, W. M., JOURNAL OF PHYSIOLOGY-LONDON 28: 220 (1902).","journal-title":"JOURNAL OF PHYSIOLOGY-LONDON"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1113\/jphysiol.1989.sp017841","volume":"418","year":"1989","unstructured":"BEECH, D.J., JOURNAL OF PHYSIOLOGY 418: 293 (1989).","journal-title":"JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1113\/jphysiol.1986.sp015961","volume":"371","year":"1986","unstructured":"BENHAM, C.D., JOURNAL OF PHYSIOLOGY 371: 45 (1986).","journal-title":"JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/323718a0","volume":"323","year":"1986","unstructured":"BLATZ, A.L., SINGLE APAMIN-BLOCKED CA-ACTIVATED K+ CHANNELS OF SMALL CONDUCTANCE IN CULTURED RAT SKELETAL-MUSCLE, NATURE 323: 718 (1986).","journal-title":"NATURE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0166-2236(87)90101-9","volume":"10","year":"1987","unstructured":"BLATZ, A.L., CALCIUM-ACTIVATED POTASSIUM CHANNELS, TRENDS IN NEUROSCIENCES 10: 463 (1987).","journal-title":"TRENDS IN NEUROSCIENCES"},{"key":"e_1_2_1_7_1","first-page":"406","volume":"84","year":"1991","unstructured":"BRAYDEN, J.E., CIRCULATION 84 2: 406 (1991).","journal-title":"CIRCULATION"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/jcbfm.1989.42","volume":"9","year":"1989","unstructured":"BRAYDEN, J.E., ENDOTHELIUM-DEPENDENT DILATION OF FELINE CEREBRAL-ARTERIES - ROLE OF MEMBRANE-POTENTIAL AND CYCLIC-NUCLEOTIDES, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 9: 256 (1989).","journal-title":"JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"C470","DOI":"10.1152\/ajpcell.1989.257.3.C470","volume":"257","year":"1989","unstructured":"CARL, A, AMERICAN JOURNAL OF PHYSIOLOGY 257: C470 (1989).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"C481","DOI":"10.1152\/ajpcell.1989.257.3.C481","volume":"257","year":"1989","unstructured":"COLE, W. C., AMERICAN JOURNAL OF PHYSIOLOGY 257: C481 (1989).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_11_1","first-page":"H108","volume":"241","year":"1981","unstructured":"DULING, B. R., AMERICAN JOURNAL OF PHYSIOLOGY 241: H108 (1981).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"11083","DOI":"10.1016\/S0021-9258(19)38560-6","volume":"265","year":"1990","unstructured":"GALVEZ, A, PURIFICATION AND CHARACTERIZATION OF A UNIQUE, POTENT, PEPTIDYL PROBE FOR THE HIGH CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL FROM VENOM OF THE SCORPION BUTHUS-TAMULUS, JOURNAL OF BIOLOGICAL CHEMISTRY 265: 11083 (1990).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00656997"},{"key":"e_1_2_1_14_1","first-page":"F778","volume":"253","year":"1987","unstructured":"HARDER, D.R., AMERICAN JOURNAL OF PHYSIOLOGY 253: F778 (1987).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1161\/01.RES.55.2.197","volume":"55","year":"1984","unstructured":"HARDER, D.R., PRESSURE-DEPENDENT MEMBRANE DEPOLARIZATION IN CAT MIDDLE CEREBRAL-ARTERY, CIRCULATION RESEARCH 55: 197 (1984).","journal-title":"CIRCULATION RESEARCH"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1161\/01.RES.60.1.102","volume":"60","year":"1987","unstructured":"HARDER, D.R., PRESSURE-INDUCED MYOGENIC ACTIVATION OF CAT CEREBRAL-ARTERIES IS DEPENDENT ON INTACT ENDOTHELIUM, CIRCULATION RESEARCH 60: 102 (1987).","journal-title":"CIRCULATION RESEARCH"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1085\/jgp.94.5.849","volume":"94","year":"1989","unstructured":"HU, S.L., PERMEATION, SELECTIVITY, AND BLOCKADE OF THE CA-2+-ACTIVATED POTASSIUM CHANNEL OF THE GUINEA-PIG TAENIA-COLI MYOCYTE, JOURNAL OF GENERAL PHYSIOLOGY 94: 849 (1989).","journal-title":"JOURNAL OF GENERAL PHYSIOLOGY"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00582557","volume":"405","year":"1985","unstructured":"INOUE, R, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 405: 173 (1985).","journal-title":"PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.RES.59.5.483","volume":"59","year":"1986","unstructured":"JOHNSON, P.C., AUTOREGULATION OF BLOOD-FLOW, CIRCULATION RESEARCH 59: 483 (1986).","journal-title":"CIRCULATION RESEARCH"},{"key":"e_1_2_1_20_1","first-page":"H604","volume":"261","year":"1991","unstructured":"KOVACS, R. J., AMERICAN JOURNAL OF PHYSIOLOGY 261: H604 (1991).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"C1204","DOI":"10.1152\/ajpcell.1991.261.6.C1204","volume":"261","year":"1991","unstructured":"KUME, H, AMERICAN JOURNAL OF PHYSIOLOGY 261: C1204 (1991).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_22_1","first-page":"H927","volume":"260","year":"1991","unstructured":"LANGTON, P. D., AMERICAN JOURNAL OF PHYSIOLOGY 260: H927 (1991).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.ph.51.030189.002125","volume":"51","year":"1989","unstructured":"LATORRE, R, VARIETIES OF CALCIUM-ACTIVATED POTASSIUM CHANNELS, ANNUAL REVIEW OF PHYSIOLOGY 51: 385 (1989).","journal-title":"ANNUAL REVIEW OF PHYSIOLOGY"},{"key":"e_1_2_1_24_1","first-page":"H287","volume":"261","year":"1991","unstructured":"MCCARRON, J.G., AMERICAN JOURNAL OF PHYSIOLOGY 261: H287 (1991).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_25_1","first-page":"H950","volume":"261","year":"1991","unstructured":"MEININGER, G.A., AMERICAN JOURNAL OF PHYSIOLOGY 261: H950 (1991).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/313316a0","volume":"313","year":"1985","unstructured":"MILLER, C, CHARYBDOTOXIN, A PROTEIN INHIBITOR OF SINGLE CA-2(+)-ACTIVATED K+ CHANNELS FROM MAMMALIAN SKELETAL-MUSCLE, NATURE 313: 316 (1985).","journal-title":"NATURE"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"C3","DOI":"10.1152\/ajpcell.1990.259.1.C3","volume":"259","year":"1990","unstructured":"NELSON, M. T., AMERICAN JOURNAL OF PHYSIOLOGY 259: C3 (1990).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/336382a0","volume":"336","year":"1988","unstructured":"NELSON, M.T., NORADRENALINE CONTRACTS ARTERIES BY ACTIVATING VOLTAGE-DEPENDENT CALCIUM CHANNELS, NATURE 336: 382 (1988).","journal-title":"NATURE"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/344770a0","volume":"344","year":"1990","unstructured":"NELSON, M.T., ARTERIAL DILATIONS IN RESPONSE TO CALCITONIN GENE-RELATED PEPTIDE INVOLVE ACTIVATION OF K+ CHANNELS, NATURE 344: 770 (1990).","journal-title":"NATURE"},{"key":"e_1_2_1_30_1","first-page":"329","volume":"225","year":"1985","unstructured":"OGDEN, D.C., ION CHANNEL BLOCK BY ACETYLCHOLINE, CARBACHOL AND SUBERYLDICHOLINE AT THE FROG NEUROMUSCULAR-JUNCTION, PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 225: 329 (1985).","journal-title":"PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_31_1","first-page":"H914","volume":"249","year":"1985","unstructured":"OSOL, G, AMERICAN JOURNAL OF PHYSIOLOGY 249: H914 (1985).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_32_1","first-page":"107","year":"1986","unstructured":"Osol, G., Essential Hypertension: 107 (1986).","journal-title":"Essential Hypertension"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0165-6147(89)80003-3","volume":"10","year":"1989","unstructured":"QUAST, U, MOVING TOGETHER - K+ CHANNEL OPENERS AND ATP-SENSITIVE K+ CHANNELS, TRENDS IN PHARMACOLOGICAL SCIENCES 10: 431 (1989).","journal-title":"TRENDS IN PHARMACOLOGICAL SCIENCES"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"A301","DOI":"10.1016\/S0006-3495(90)82532-7","volume":"57","year":"1990","unstructured":"QUAYLE, J. M., BIOPHYSICAL JOURNAL 57: A301 (1990).","journal-title":"BIOPHYSICAL JOURNAL"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1113\/jphysiol.1988.sp017355","volume":"405","year":"1988","unstructured":"QUAYLE, J. M., JOURNAL OF PHYSIOLOGY-LONDON 405: 677 (1988).","journal-title":"JOURNAL OF PHYSIOLOGY-LONDON"},{"key":"e_1_2_1_36_1","first-page":"H783","volume":"255","year":"1988","unstructured":"RUBANYI, G. M., AMERICAN JOURNAL OF PHYSIOLOGY 255: H783 (1988).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/BF00581337","volume":"408","year":"1987","unstructured":"SINGER, J. J., PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 408: 98 (1987).","journal-title":"PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2501869"},{"key":"e_1_2_1_39_1","first-page":"H912","volume":"258","year":"1990","unstructured":"TORO, L, AMERICAN JOURNAL OF PHYSIOLOGY 258: H912 (1990).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_40_1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/BF00785811","volume":"23","year":"1991","unstructured":"TORO, L, CALCIUM-ACTIVATED K+ CHANNELS - METABOLIC-REGULATION, JOURNAL OF BIOENERGETICS AND BIOMEMBRANES 23: 561 (1991).","journal-title":"JOURNAL OF BIOENERGETICS AND BIOMEMBRANES"},{"key":"e_1_2_1_41_1","first-page":"H1951","volume":"261","year":"1991","unstructured":"WORLEY, J. F., AMERICAN JOURNAL OF PHYSIOLOGY 261: H1951 (1991).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1373909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T03:53:42Z","timestamp":1704945222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1373909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4,24]]},"references-count":41,"journal-issue":{"issue":"5056","published-print":{"date-parts":[[1992,4,24]]}},"alternative-id":["10.1126\/science.1373909"],"URL":"https:\/\/doi.org\/10.1126\/science.1373909","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4,24]]}}}