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It seems likely that a toxic compound is produced by the action of ultraviolet light on a 7-hydroxylated chlorpromazine derivative deposited in skin, cornea, and lens, and that this in turn leads to excessive melanin production and eye changes.<\/jats:p>","DOI":"10.1126\/science.146.3640.81","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T09:47:29Z","timestamp":1160041649000},"page":"81-83","source":"Crossref","is-referenced-by-count":52,"title":["7-Hydroxychlorpromazine: Potential Toxic Drug Metabolite in Psychiatric Patients"],"prefix":"10.1126","volume":"146","author":[{"given":"Thomas L.","family":"Perry","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and Pathology, University of British Columbia, Vancouver, Canada, and Provincial Mental Hospital, Essondale, British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F. A.","family":"Culling","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Pathology, University of British Columbia, Vancouver, Canada, and Provincial Mental Hospital, Essondale, British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Berry","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Pathology, University of British Columbia, Vancouver, Canada, and Provincial Mental Hospital, Essondale, British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Hansen","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Pathology, University of British Columbia, Vancouver, Canada, and Provincial Mental Hospital, Essondale, British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1751-0813.1947.tb04499.x","volume":"23","year":"1947","unstructured":"CLARE, N. 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