{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:54:57Z","timestamp":1758279297943},"reference-count":7,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3695","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1965,10,22]]},"abstract":"<jats:p>\n            Homozygous (\n            <jats:italic>f<\/jats:italic>\n            \/\n            <jats:italic>f<\/jats:italic>\n            ) but not heterozygous (\n            <jats:italic>f<\/jats:italic>\n            \/+) mice of the highly congenic strain, FL\/ Re, manifest a severe transitory siderocytic fetal anemia. Adults of both\n            <jats:italic>f<\/jats:italic>\n            \/\n            <jats:italic>f<\/jats:italic>\n            and\n            <jats:italic>f<\/jats:italic>\n            \/+ genotype manifest decreased hepatic, splenic, and renal levels of \u0394-aminolevulinate dehydratase (ALD) activity compared to homozygous (+\/+) mice of the same strain. The degree of augmentation in splenic ALD activity following phenylhydrazine administration is high in +\/+, intermediate in\n            <jats:italic>f<\/jats:italic>\n            \/+, and low in\n            <jats:italic>f<\/jats:italic>\n            \/\n            <jats:italic>f<\/jats:italic>\n            mice. These findings suggest that perhaps a deficiency in the fetal level of ALD may be responsible for the transitory fetal anemia.\n          <\/jats:p>","DOI":"10.1126\/science.150.3695.496","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T10:04:55Z","timestamp":1160042695000},"page":"496-497","source":"Crossref","is-referenced-by-count":7,"title":["Delta-Aminolevulinate Dehydratase Activity in Mice with Hereditary Anemia"],"prefix":"10.1126","volume":"150","author":[{"given":"Frank L.","family":"Margolis","sequence":"first","affiliation":[{"name":"Department of Medicine, College of Physicians and Surgeons, Columbia University, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth S.","family":"Russell","sequence":"additional","affiliation":[{"name":"Jackson Laboratory, Bar Harbor, Maine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1042\/bj0610618","volume":"61","year":"1955","unstructured":"GIBSON, K.D., BIOCHEMICAL JOURNAL 61: 618 (1955).","journal-title":"BIOCHEMICAL JOURNAL"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF02982746","volume":"43","year":"1942","unstructured":"GRUNEBERG, H, The anaemia of flexed-tailed mice (Mus musculus L.) I. Static and dynamic haematology, JOURNAL OF GENETICS 43: 45 (1942).","journal-title":"JOURNAL OF GENETICS"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/BF02982831","volume":"44","year":"1942","unstructured":"GRUNEBERG, H, The anaemia of flexed-tailed mice (Mus musculus L.) II. Siderocytes, JOURNAL OF GENETICS 44: 246 (1942).","journal-title":"JOURNAL OF GENETICS"},{"key":"e_1_2_1_4_1","first-page":"1883","volume":"24","year":"1965","unstructured":"MARGOLIS, F, FEDERATION PROCEEDINGS 24: 1883 (1965).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_5_1","first-page":"240","volume":"24","year":"1965","unstructured":"RUSSELL, E.S., ERYTHROCYTE POPULATIONS IN FETAL MICE WITH AND WITHOUT 2 DIFFERENT HEREDITARY ANEMIAS, FEDERATION PROCEEDINGS 24: 240 (1965).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/genetics\/48.8.1033","volume":"48","year":"1963","unstructured":"RUSSELL, R.L., GENETIC CONTROL OF HEPATIC DELTA-AMINOLEVULINATE DEHYDRATASE IN MICE, GENETICS 48: 1033 (1963).","journal-title":"GENETICS"},{"key":"e_1_2_1_7_1","first-page":"7","year":"1964","unstructured":"Wilcoxon, F., Some Rapid Approximate Statistical Procedures: 7 (1964).","journal-title":"Some Rapid Approximate Statistical Procedures"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.150.3695.496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T03:45:44Z","timestamp":1704944744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.150.3695.496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,10,22]]},"references-count":7,"journal-issue":{"issue":"3695","published-print":{"date-parts":[[1965,10,22]]}},"alternative-id":["10.1126\/science.150.3695.496"],"URL":"https:\/\/doi.org\/10.1126\/science.150.3695.496","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1965,10,22]]}}}