{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:05:16Z","timestamp":1705017916434},"reference-count":25,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3699","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1965,11,19]]},"abstract":"<jats:p>In comparison with mature animals, pre-weanling rats have markedly higher and longer lasting serum levels of \u03b2-phenyllactate following the intraperitoneal injection of a moderate dose. A corresponding age-dependent difference in the rate of oxidation of \u03b2-phenyllactate and other \u03b1-hydroxy acids was observed in experiments with homogenates and supernatant fractions of rat kidney.<\/jats:p>","DOI":"10.1126\/science.150.3699.1042","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T10:04:55Z","timestamp":1160042695000},"page":"1042-1044","source":"Crossref","is-referenced-by-count":2,"title":["Phenylketonuria: Limit in Capacity of Pre-Weanling Rats To Oxidize \u03b2-Phenyllactate and Other \u03b1-Hydroxy Acids"],"prefix":"10.1126","volume":"150","author":[{"given":"Fred B.","family":"Goldstein","sequence":"first","affiliation":[{"name":"Research Department, Letchworth Village, New York State Department of Mental Hygiene, Thiells"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0003-9861(52)90461-X","volume":"41","year":"1952","unstructured":"BAKER, C.G., ENZYMATIC OXIDATION OF D-ALPHA-HYDROXY AND L-ALPHA-HYDROXY ACIDS, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 41: 325 (1952).","journal-title":"ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0021-9258(18)51172-8","volume":"155","year":"1944","unstructured":"BLANCHARD, M, l-amino acid oxidase of animal tissue, JOURNAL OF BIOLOGICAL CHEMISTRY 155: 421 (1944).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0021-9258(17)41492-X","volume":"161","year":"1945","unstructured":"BLANCHARD, M, ISOLATION OF L-AMINO ACID OXIDASE, JOURNAL OF BIOLOGICAL CHEMISTRY 161: 583 (1945).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1515\/bchm2.1938.254.2.107","volume":"254","year":"1938","unstructured":"CLOSS, K, HOPPE-SEYLER'S ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 254: 107 (1938).","journal-title":"HOPPE-SEYLER'S ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE"},{"key":"e_1_2_1_5_1","first-page":"254","volume":"254","year":"1938","unstructured":"CLOSS, K, HOPPE-SEYLER'S ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 254: 254 (1938).","journal-title":"HOPPE-SEYLER'S ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3181\/00379727-93-22773","volume":"93","year":"1956","unstructured":"FELLMAN, J.H., INHIBITION OF DOPA DECARBOXYLASE BY AROMATIC ACIDS ASSOCIATED WITH PHENYLPYRUVIC OLIGOPHRENIA, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 93: 413 (1956).","journal-title":"PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0006-291X(61)90135-8","volume":"6","year":"1961","unstructured":"FREEDLAND, R.A., EFFECT OF AROMATIC AMINO ACIDS ON HYDROXYLATION OF TRYPTOPHAN, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 6: 227 (1961).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1016\/S0021-9258(19)61715-1","volume":"236","year":"1961","unstructured":"GOLDSTEIN, F.B., BIOCHEMICAL STUDIES ON PHENYLKETONURIA .1. EXPERIMENTAL HYPERPHENYLALANEMIA IN RAT, JOURNAL OF BIOLOGICAL CHEMISTRY 236: 2656 (1961).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_9_1","unstructured":"GOLDSTEIN F.B. UNPUBLISHED."},{"key":"e_1_2_1_10_1","first-page":"170","year":"1955","unstructured":"GUSTAFSON, T, VEGETALIZATION AND ANIMALIZATION IN THE SEA URCHIN EGG INDUCED BY ANTIMETABOLITES - PRELIMINARY NOTE, EXPERIMENTAL CELL RESEARCH: 170 (1955).","journal-title":"EXPERIMENTAL CELL RESEARCH"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3181\/00379727-112-27956","volume":"112","year":"1963","unstructured":"HUANG, I, STUDIES ON INHIBITION OF 5-HYDROXY TRYPTOPHAN DECARBOXYLASE BY PHENYLALANINE METABOLITES, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 112: 81 (1963).","journal-title":"PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1002\/hlca.19460290618","volume":"29","year":"1946","unstructured":"ISELIN, B, HELVETICA CHIMICA ACTA 29: 1508 (1946).","journal-title":"HELVETICA CHIMICA ACTA"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/bj0900149","volume":"90","year":"1964","unstructured":"KREBS, H.A., INHIBITION OF GLUCONEOGENESIS BY ALPHA-OXO ACIDS, BIOCHEMICAL JOURNAL 90: 149 (1964).","journal-title":"BIOCHEMICAL JOURNAL"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1542\/peds.31.1.39","volume":"31","year":"1963","unstructured":"LADU, B.N., A QUANTITATIVE MICROMETHOD FOR DETERMINATION OF PHENYLALANINE AND TYROSINE IN BLOOD AND ITS APPLICATION IN DIAGNOSIS OF PHENYLKETONURIA IN INFANTS, PEDIATRICS 31: 39 (1963).","journal-title":"PEDIATRICS"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01318a036"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0021-9258(19)51130-9","volume":"184","year":"1950","unstructured":"MEISTER, A, REDUCTION OF ALPHA-GAMMA-DIKETO AND ALPHA-KETO ACIDS CATALYZED BY MUSCLE PREPARATIONS AND BY CRYSTALLINE LACTIC DEHYDROGENASE, JOURNAL OF BIOLOGICAL CHEMISTRY 184: 117 (1950).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1212\/WNL.9.12.826","volume":"9","year":"1959","unstructured":"MENKES, J.H., MAPLE SYRUP DISEASE - INVESTIGATIONS INTO THE METABOLIC DEFECT, NEUROLOGY 9: 826 (1959).","journal-title":"NEUROLOGY"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1042\/bj0310266","volume":"31","year":"1937","unstructured":"PENROSE, L, Metabolic studies in phenylketonuria, BIOCHEMICAL JOURNAL 31: 266 (1937).","journal-title":"BIOCHEMICAL JOURNAL"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0021-9258(19)73973-8","volume":"237","year":"1962","unstructured":"ROBINSON, J.C., L-ALPHA-HYDROXY ACID OXIDASES OF HOG RENAL CORTEX, JOURNAL OF BIOLOGICAL CHEMISTRY 237: 2001 (1962).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_20_1","first-page":"331","volume":"96","year":"1965","unstructured":"SKYE, G.E., REDUCTION OF AROMATIC KETO ACIDS BY RAT LIVER, BIOCHIMICA ET BIOPHYSICA ACTA 96: 331 (1965).","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1515\/bchm2.1911.72.1-2.113","volume":"72","year":"1911","unstructured":"SUWA, A, HOPPE-SEYLER'S ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 72: 113 (1911).","journal-title":"HOPPE-SEYLER'S ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1471-4159.1963.tb11904.x","volume":"10","year":"1963","unstructured":"UZMAN, L.L., INHIBITION OF CEREBRAL DIGLYCINASE BY ALPHA-AMINO-, ALPHA-KETO- AND ALPHA-HYDROXY ACIDS, JOURNAL OF NEUROCHEMISTRY 10: 795 (1963).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_23_1","first-page":"475","volume":"23","year":"1964","unstructured":"WEBER, W.W., ENZYMATIC REDUCTION OF ALPHA-KETO ACIDS OF PHENYLALANINE + TYROSINE, FEDERATION PROCEEDINGS 23: 475 (1964).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jmor.1050970205","volume":"97","year":"1955","unstructured":"WILDE, C.E., JOURNAL OF MORPHOLOGY 97: 313 (1955).","journal-title":"JOURNAL OF MORPHOLOGY"},{"key":"e_1_2_1_25_1","first-page":"C19","volume":"3","year":"1945","unstructured":"ZELLER, E.A., HELVETICA PHYSIOLOGICA ET PHARMACOLOGICA ACTA 3: C19 (1945).","journal-title":"HELVETICA PHYSIOLOGICA ET PHARMACOLOGICA ACTA"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.150.3699.1042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T08:19:43Z","timestamp":1704961183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.150.3699.1042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,11,19]]},"references-count":25,"journal-issue":{"issue":"3699","published-print":{"date-parts":[[1965,11,19]]}},"alternative-id":["10.1126\/science.150.3699.1042"],"URL":"https:\/\/doi.org\/10.1126\/science.150.3699.1042","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1965,11,19]]}}}