{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:30:21Z","timestamp":1759541421843},"reference-count":20,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3700","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1965,11,26]]},"abstract":"<jats:p>\n            Guinea pigs injected with 100 micrograms of\n            <jats:italic>p<\/jats:italic>\n            -azobenzenearsonate derivatives of hexa-L-tyrosine, tri-L-tyrosine, or\n            <jats:italic>N<\/jats:italic>\n            -acetyl-L-tyrosine amide, in complete Freund's adjuvant, developed, after 10 to 19 days, delayed-type hypersensitivity to these substances. This was shown by skin reactions, followed by the formation of circulating antibodies that were detectable by passive cutaneous anaphylaxis. Experiments with\n            <jats:italic>p<\/jats:italic>\n            -azobenzenearsonate-hexa-L-tyrosine labeled with iodine-131 showed that this substance was bound in vitro to proteins of normal guinea pig serum. Binding was similar with the nonantigenic hexa-L-tyrosine and its\n            <jats:italic>p<\/jats:italic>\n            -azobenzoate derivative.\n          <\/jats:p>","DOI":"10.1126\/science.150.3700.1177","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T10:04:55Z","timestamp":1160042695000},"page":"1177-1178","source":"Crossref","is-referenced-by-count":32,"title":["Immunogenicity and Role of Size: Response of Guinea Pigs to Oligotyrosine and Tyrosine Derivatives"],"prefix":"10.1126","volume":"150","author":[{"given":"Felix","family":"Borek","sequence":"first","affiliation":[{"name":"Section of Chemical Immunology, Weizmann Institute of Science, Rehovoth, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehudit","family":"Stupp","sequence":"additional","affiliation":[{"name":"Section of Chemical Immunology, Weizmann Institute of Science, Rehovoth, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sela","sequence":"additional","affiliation":[{"name":"Section of Chemical Immunology, Weizmann Institute of Science, Rehovoth, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4049\/jimmunol.95.1.113","volume":"95","year":"1965","unstructured":"ABUELO, J.G., DINITROPHENYLATED BACITRACIN A AS AN ANTIGEN IN GUINEA PIG, JOURNAL OF IMMUNOLOGY 95: 113 (1965).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/206362a0","volume":"206","year":"1965","unstructured":"BATCHELOR, F.R., PENICILLIN ALLERGY - FORMATION OF PENICILLOYL DETERMINANT, NATURE 206: 362 (1965).","journal-title":"NATURE"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/206523a0","volume":"206","year":"1965","unstructured":"BERGLUND, G, PREPARATION OF ANTISERUM TO AN ANTIGEN OF LOW MOLECULAR WEIGHT, NATURE 206: 523 (1965).","journal-title":"NATURE"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0019-2791(65)90032-7","volume":"2","year":"1965","unstructured":"Borek, F., Immunochemistry 2: 323 (1965).","journal-title":"Immunochemistry"},{"key":"e_1_2_1_5_1","unstructured":"BOREK F UNPUBLISHED DATA."},{"key":"e_1_2_1_6_1","first-page":"89","year":"1959","unstructured":"Eisen, H. 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