{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:18:05Z","timestamp":1759335485323},"reference-count":12,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3730","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1966,6,24]]},"abstract":"<jats:p>A specific congenital ataxia may be caused by presence of mutant genes and by manganese deficiency during prenatal development in normal mice. Supplementation of the diet of mutant mice with manganese during prenatal development rectifies the aberrant development, resulting in normal behavior. The congenital ataxia results from defective development of the otoliths.<\/jats:p>","DOI":"10.1126\/science.152.3730.1766","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T10:47:55Z","timestamp":1160045275000},"page":"1766-1768","source":"Crossref","is-referenced-by-count":77,"title":["Neurological Defect: Manganese in Phenocopy and Prevention of a Genetic Abnormality of Inner Ear"],"prefix":"10.1126","volume":"152","author":[{"given":"Lawrence","family":"Erway","sequence":"first","affiliation":[{"name":"Departments of Genetics and Nutrition, University of California, Davis 95616"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucille S.","family":"Hurley","sequence":"additional","affiliation":[{"name":"Departments of Genetics and Nutrition, University of California, Davis 95616"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Fraser","sequence":"additional","affiliation":[{"name":"Departments of Genetics and Nutrition, University of California, Davis 95616"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"713","volume":"23","year":"1964","unstructured":"COTZIAS, G.C., MELANOGENESIS + EXTRAPYRAMIDAL DISEASES, FEDERATION PROCEEDINGS 23: 713 (1964).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/2011228a0","volume":"201","year":"1964","unstructured":"COTZIAS, G.C., MANGANESE IN MELANIN, NATURE 201: 1228 (1964).","journal-title":"NATURE"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/jn\/66.3.309","volume":"66","year":"1958","unstructured":"HURLEY, L.S., MANGANESE DEFICIENCY IN RATS - CONGENITAL NATURE OF ATAXIA, JOURNAL OF NUTRITION 66: 309 (1958).","journal-title":"JOURNAL OF NUTRITION"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/jn\/71.1.15","volume":"71","year":"1960","unstructured":"HURLEY, L.S., ANOMALOUS DEVELOPMENT OF OSSIFICATION IN THE INNER EAR OF OFFSPRING OF MANGANESE-DEFICIENT RATS, JOURNAL OF NUTRITION 71: 15 (1960).","journal-title":"JOURNAL OF NUTRITION"},{"key":"e_1_2_1_5_1","first-page":"213","volume":"3","year":"1955","unstructured":"LYON, M.F., THE DEVELOPMENT OF THE OTOLITHS OF THE MOUSE, JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY 3: 213 (1955).","journal-title":"JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/BF02982950","volume":"51","year":"1953","unstructured":"LYON, M.F., ABSENCE OF OTOLITHS IN THE MOUSE - AN EFFECT OF THE PALLID MUTANT, JOURNAL OF GENETICS 51: 638 (1953).","journal-title":"JOURNAL OF GENETICS"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1113\/jphysiol.1951.sp004632","volume":"114","year":"1951","unstructured":"LYON, M.F., HEREDITARY ABSENCE OF OTOLITHS IN THE HOUSE MOUSE, JOURNAL OF PHYSIOLOGY-LONDON 114: 410 (1951).","journal-title":"JOURNAL OF PHYSIOLOGY-LONDON"},{"key":"e_1_2_1_8_1","first-page":"38","volume":"32","year":"1965","unstructured":"LYON, M.F., MOUSE NEWS LETTER 32: 38 (1965).","journal-title":"MOUSE NEWS LETTER"},{"key":"e_1_2_1_9_1","first-page":"289","volume":"86","year":"1954","unstructured":"LYON, M.F., STAGE OF ACTION OF THE LITTER-SIZE EFFECT ON ABSENCE OF OTOLITHS IN MICE, ZEITSCHRIFT FUR INDUKTIVE ABSTAMMUNGS UND VERERBUNGSLEHRE 86: 289 (1954).","journal-title":"ZEITSCHRIFT FUR INDUKTIVE ABSTAMMUNGS UND VERERBUNGSLEHRE"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0012-1606(64)90025-9","volume":"9","year":"1964","unstructured":"MAYER, T.C., EXPERIMENTAL INVESTIGATION OF PATTERN DEVELOPMENT IN LETHAL SPOTTING + BELTED MOUSE EMBRYOS, DEVELOPMENTAL BIOLOGY 9: 269 (1964).","journal-title":"DEVELOPMENTAL BIOLOGY"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0012-1606(65)90042-4","volume":"11","year":"1965","unstructured":"MAYER, T.C., DEVELOPMENT OF PIEBALD SPOTTING IN MICE, DEVELOPMENTAL BIOLOGY 11: 319 (1965).","journal-title":"DEVELOPMENTAL BIOLOGY"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/208810a0","volume":"208","year":"1965","unstructured":"VANWOERT, M.H., FUNCTIONAL SIMILARITIES BETWEEN CYTOPLASMIC ORGANELLES OF MELANOCYTES AND MITOCHONDRIA OF HEPATOCYTES, NATURE 208: 810 (1965).","journal-title":"NATURE"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.152.3730.1766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T09:18:27Z","timestamp":1704964707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.152.3730.1766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,6,24]]},"references-count":12,"journal-issue":{"issue":"3730","published-print":{"date-parts":[[1966,6,24]]}},"alternative-id":["10.1126\/science.152.3730.1766"],"URL":"https:\/\/doi.org\/10.1126\/science.152.3730.1766","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,6,24]]}}}