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The strategy also incorporates a 1,4-dihydrotrigonellinate targetor that undergoes an enzymatically mediated oxidation to a hydrophilic, membrane-impermeable trigonellinate salt. The polar targetorpeptide conjugate that is trapped behind the lipoidal blood-brain barrier is deposited in the central nervous system. Analgesia was observed with \"packaged\" enkephalin but not with the unmodified peptide or lipophilic peptide precursors.<\/jats:p>","DOI":"10.1126\/science.1529356","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:03:06Z","timestamp":1160089386000},"page":"1698-1700","source":"Crossref","is-referenced-by-count":111,"title":["A Strategy for Delivering Peptides into the Central Nervous System by Sequential Metabolism"],"prefix":"10.1126","volume":"257","author":[{"given":"Nicholas","family":"Bodor","sequence":"first","affiliation":[{"name":"Center for Drug Discovery, College of Pharmacy, J. 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