{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:08:50Z","timestamp":1789945730275,"version":"4.0.1"},"reference-count":8,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3752","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1966,11,25]]},"abstract":"<jats:p>Emergence of adult mosquitoes is blocked after the addition of 1 part of crude synthetic juvenile hormone to 100,000 parts water. Development is arrested at stages ranging from pupae to fully formed pharate adults incapable of escaping from the pupal exuvium. Fourth-stage larvae just prior to metamorphosis are most sensitive: 40 percent were killed after being exposed for 1 day to 1 part juvenile hormone in 2 million parts water. The active material also inhibits the hatching of mosquito eggs.<\/jats:p>","DOI":"10.1126\/science.154.3752.1043","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T10:47:55Z","timestamp":1160045275000},"page":"1043-1044","source":"Crossref","is-referenced-by-count":55,"title":["Lethal Effects of Synthetic Juvenile Hormone on Larvae of the Yellow Fever Mosquito,\n            <i>Aedes aegypti<\/i>"],"prefix":"10.1126","volume":"154","author":[{"given":"Andrew","family":"Spielman","sequence":"first","affiliation":[{"name":"Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carroll M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Biological Laboratories, Harvard University, Cambridge, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"576","volume":"55","year":"1966","unstructured":"LAW, J.H., SYNTHESIS OF A MATERIAL WITH HIGH JUVENILE HORMONE ACTIVITY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 55: 576 (1966).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_2_1","first-page":"595","volume":"57","year":"1967","unstructured":"Riddiford, L. M., Proceedings of the National Academy of Sciences of the United States of America 57: 595 (1967).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/0022-1910(65)90031-4","volume":"11","year":"1965","unstructured":"Schneiderman, H. A., Journal of Insect Physiology 11: 1641 (1965).","journal-title":"Journal of Insect Physiology"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2307\/1539700","volume":"130","year":"1966","unstructured":"SLAMA, K, JUVENILE HORMONE .V. SENSITIVITY OF BUG PYRRHOCORIS APTERUS TO A HORMONALLY ACTIVE FACTOR INAMERICAN PAPER-PULP, BIOLOGICAL BULLETIN 130: 235 (1966).","journal-title":"BIOLOGICAL BULLETIN"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/210329a0","volume":"210","year":"1966","unstructured":"SLAMA, K, PAPER FACTOR AS AN INHIBITOR OF EMBRYONIC DEVELOPMENT OF EUROPEAN BUG PYRRHOCORIS APTERUS, NATURE 210: 329 (1966).","journal-title":"NATURE"},{"key":"e_1_2_1_6_1","first-page":"411","volume":"54","year":"1965","unstructured":"SLAMA, K, JUVENILE HORMONE ACTIVITY FOR BUG PYRRHOCORIS APTERUS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 54: 411 (1965).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_7_1","first-page":"212","volume":"178","year":"1956","unstructured":"WILLIAMS, C.M., JUVENILE HORMONE OF INSECTS, NATURE 178: 212 (1956).","journal-title":"NATURE"},{"key":"e_1_2_1_8_1","unstructured":"WILLIAMS C.M. UNPUBLISHED FINDINGS."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.154.3752.1043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T09:23:57Z","timestamp":1704965037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.154.3752.1043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,11,25]]},"references-count":8,"journal-issue":{"issue":"3752","published-print":{"date-parts":[[1966,11,25]]}},"alternative-id":["10.1126\/science.154.3752.1043"],"URL":"https:\/\/doi.org\/10.1126\/science.154.3752.1043","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,11,25]]}}}