{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:52:17Z","timestamp":1789786337586,"version":"4.0.1"},"reference-count":18,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5050","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1992,3,13]]},"abstract":"<jats:p>Oncostatin M, a cytokine produced by activated lymphoid cells, regulates the growth and differentiation of a number of tumor and normal cells. In contrast to its effects on normal endothelial and aortic smooth muscle cell cultures, Oncostatin M was a potent mitogen for cells derived from acquired immunodeficiency syndrome-related Kaposi's sarcoma (AIDS-KS). After exposure to Oncostatin M, AIDS-KS cells assumed a spindle morphology, had an increased ability to proliferate in soft agar, and secreted increased amounts of interleukin-6. Oncostatin M RNA and immunoreactive Oncostatin M protein were found in AIDS-KS-derived cell isolates. These results suggest that Oncostatin M may play a role in the pathogenesis of AIDS-KS.<\/jats:p>","DOI":"10.1126\/science.1542793","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:03:06Z","timestamp":1160089386000},"page":"1432-1434","source":"Crossref","is-referenced-by-count":192,"title":["Oncostatin M as a Potent Mitogen for AIDS-Kaposi's Sarcoma-Derived Cells"],"prefix":"10.1126","volume":"255","author":[{"given":"Steven A.","family":"Miles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oton\u00edel","family":"Mart\u00ednez-Maza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Rezai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Magpantay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taditnitsu","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan F.","family":"Radka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Linsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/BF00915059","volume":"7","year":"1987","unstructured":"AMMANN, A.J., TUMOR NECROSIS FACTORS ALPHA AND BETA IN ACQUIRED-IMMUNODEFICIENCY-SYNDROME (AIDS) AND AIDS-RELATED COMPLEX, JOURNAL OF CLINICAL IMMUNOLOGY 7: 481 (1987).","journal-title":"JOURNAL OF CLINICAL IMMUNOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0090-1229(87)90180-2","volume":"42","year":"1987","unstructured":"BERMAN, M.A., INTERLEUKIN-1 INHIBITOR MASKS HIGH INTERLEUKIN-1 PRODUCTION IN ACQUIRED-IMMUNODEFICIENCY-SYNDROME (AIDS), CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY 42: 133 (1987).","journal-title":"CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.4049\/jimmunol.139.9.2977","volume":"139","year":"1987","unstructured":"BROWN, T.J., PURIFICATION AND CHARACTERIZATION OF CYTOSTATIC LYMPHOKINES PRODUCED BY ACTIVATED HUMAN LYMPHOCYTES-T - SYNERGISTIC ANTIPROLIFERATIVE ACTIVITY OF TRANSFORMING GROWTH FACTOR-BETA-1, INTERFERON-GAMMA, AND ONCOSTATIN-M FOR HUMAN-MELANOMA CELLS, JOURNAL OF IMMUNOLOGY 139: 2977 (1987).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.4049\/jimmunol.147.7.2175","volume":"147","year":"1991","unstructured":"BROWN, T.J., REGULATION OF IL-6 EXPRESSION BY ONCOSTATIN-M, JOURNAL OF IMMUNOLOGY 147: 2175 (1991).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/345084a0","volume":"345","year":"1990","unstructured":"ENSOLI, B, TAT PROTEIN OF HIV-1 STIMULATES GROWTH OF CELLS DERIVED FROM KAPOSIS-SARCOMA LESIONS OF AIDS PATIENTS, NATURE 345: 84 (1990).","journal-title":"NATURE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2643161"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/08977199009071502","volume":"2","year":"1990","unstructured":"HORN, D, GROWTH FACTORS 2: 157 (1990).","journal-title":"GROWTH FACTORS"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1200\/JCO.1984.2.10.1115","volume":"2","year":"1984","unstructured":"LAUBENSTEIN, L.J., TREATMENT OF EPIDEMIC KAPOSIS SARCOMA WITH ETOPOSIDE OR A COMBINATION OF DOXORUBICIN, BLEOMYCIN, AND VINBLASTINE, JOURNAL OF CLINICAL ONCOLOGY 2: 1115 (1984).","journal-title":"JOURNAL OF CLINICAL ONCOLOGY"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1016\/S0021-9258(18)83737-1","volume":"264","year":"1989","unstructured":"LINSLEY, P.S., IDENTIFICATION AND CHARACTERIZATION OF CELLULAR RECEPTORS FOR THE GROWTH-REGULATOR, ONCOSTATIN-M, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 4282 (1989).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_10_1","first-page":"1882","volume":"10","year":"1990","unstructured":"LINSLEY, P.S., CLEAVAGE OF A HYDROPHILIC C-TERMINAL DOMAIN INCREASES GROWTH-INHIBITORY ACTIVITY OF ONCOSTATIN-M, MOLECULAR AND CELLULAR BIOLOGY 10: 1882 (1990).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_11_1","first-page":"2847","volume":"9","year":"1989","unstructured":"MALIK, N, MOLECULAR-CLONING, SEQUENCE-ANALYSIS, AND FUNCTIONAL EXPRESSION OF A NOVEL GROWTH-REGULATOR, ONCOSTATIN-M, MOLECULAR AND CELLULAR BIOLOGY 9: 2847 (1989).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_12_1","first-page":"4068","volume":"87","year":"1990","unstructured":"MILES, S.A., AIDS KAPOSI SARCOMA-DERIVED CELLS PRODUCE AND RESPOND TO INTERLEUKIN-6, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 4068 (1990).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_13_1","unstructured":"MILES S.A. unpublished data."},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0268-960X(88)90011-2","volume":"2","year":"1988","unstructured":"MITSUYASU, R.T., AIDS-RELATED KAPOSIS SARCOMA - A REVIEW OF ITS PATHOGENESIS AND TREATMENT, BLOOD REVIEWS 2: 222 (1988).","journal-title":"BLOOD REVIEWS"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3262925"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2459779"},{"key":"e_1_2_1_17_1","first-page":"345","year":"1989","unstructured":"Volberding, P., AIDS Pathogenesis and Treatment: 345 (1989).","journal-title":"AIDS Pathogenesis and Treatment"},{"key":"e_1_2_1_18_1","first-page":"9739","volume":"83","year":"1986","unstructured":"ZARLING, J.M., ONCOSTATIN-M - A GROWTH-REGULATOR PRODUCED BY DIFFERENTIATED HISTIOCYTIC LYMPHOMA-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 9739 (1986).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1542793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T08:32:41Z","timestamp":1704961961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1542793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3,13]]},"references-count":18,"journal-issue":{"issue":"5050","published-print":{"date-parts":[[1992,3,13]]}},"alternative-id":["10.1126\/science.1542793"],"URL":"https:\/\/doi.org\/10.1126\/science.1542793","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3,13]]}}}