{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T01:59:10Z","timestamp":1744163950459},"reference-count":17,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3773","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1967,4,21]]},"abstract":"<jats:p>A virus has been isolated and serially passed in suckling rats; it causes an acute fatal paralysis associated with hemorrhage and necrosis in the brain and spinal cord. The agent is relatively resistant to heat and ether, is about 20 millimicrons in diameter, and is antigenically closely related to rat virus. Its isolation resulted from the study of occasional cases of paralysis in adult rats after administration of cyclophosphamide.<\/jats:p>","DOI":"10.1126\/science.156.3773.392","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T11:08:12Z","timestamp":1160046492000},"page":"392-394","source":"Crossref","is-referenced-by-count":29,"title":["Viral Hemorrhagic Encephalopathy of Rats"],"prefix":"10.1126","volume":"156","author":[{"given":"Adnan H.","family":"ElDadah","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University, School of Hygiene, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal","family":"Nathanson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University, School of Hygiene, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendall O.","family":"Smith","sequence":"additional","affiliation":[{"name":"National Institutes of Health, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Squire","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Medicine, and Animal Medicine, Johns Hopkins University, School of Medicine, Baltimore 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George W.","family":"Santos","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Medicine, and Animal Medicine, Johns Hopkins University, School of Medicine, Baltimore 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward C.","family":"Melby","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Medicine, and Animal Medicine, Johns Hopkins University, School of Medicine, Baltimore 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","unstructured":"Andrewes C. Viruses of Vertebrates (1964)."},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1099\/00221287-3-2-290","volume":"3","year":"1949","unstructured":"ANDREWES, C.H., THE SUSCEPTIBILITY OF VIRUSES TO ETHYL ETHER, JOURNAL OF GENERAL MICROBIOLOGY 3: 290 (1949).","journal-title":"JOURNAL OF GENERAL MICROBIOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.149.3685.754"},{"key":"e_1_2_1_4_1","unstructured":"CASALS J PERSONAL COMMUNICATION."},{"key":"e_1_2_1_5_1","first-page":"1467","volume":"55","year":"1966","unstructured":"HOGGAN, M.D., STUDIES OF SMALL DNA VIRUSES FOUND IN VARIOUS ADENOVIRUS PREPARATIONS - PHYSICAL BIOLOGICAL AND IMMUNOLOGICAL CHARACTERISTICS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 55: 1467 (1966).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_6_1","unstructured":"Holdenried R. Symposium on Virutses of Laboratory Rodents (1966)."},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","unstructured":"Innes J. R. M. Comparative Neturopathology (1962).","DOI":"10.1016\/B978-1-4832-3157-0.50008-7"},{"key":"e_1_2_1_8_1","first-page":"457","volume":"49","year":"1966","unstructured":"KILHAM, L, SPONTANEOUS HEPATITIS AND CEREBELLAR HYPOPLASIA IN SUCKLING RATS DUE TO CONGENITAL INFECTIONS WITH RAT VIRUS, AMERICAN JOURNAL OF PATHOLOGY 49: 457 (1966).","journal-title":"AMERICAN JOURNAL OF PATHOLOGY"},{"key":"e_1_2_1_9_1","unstructured":"KILHAM L PERSONAL COMMUNICATION."},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0042-6822(59)90071-6","volume":"7","year":"1959","unstructured":"KILHAM, L, A LATENT VIRUS OF RATS ISOLATED IN TISSUE CULTURE, VIROLOGY 7: 428 (1959).","journal-title":"VIROLOGY"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/infdis\/115.5.465","volume":"115","year":"1965","unstructured":"MERCADO, J, J INFECT DISEASES 115: 465 (1965).","journal-title":"J INFECT DISEASES"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.4049\/jimmunol.97.6.754","volume":"97","year":"1966","unstructured":"SMITH, K.O., PROPERTIES OF A SMALL VIRUS ASSOCIATED WITH ADENOVIRUS TYPE 4, JOURNAL OF IMMUNOLOGY 97: 754 (1966).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.145.3637.1190"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/0042-6822(62)90143-5","volume":"17","year":"1962","unstructured":"SMITH, K.O., METHOD FOR STAINING VIRUS PARTICLES AND IDENTIFYING THEIR NUCLEIC ACID TYPE IN ELECTRON MICROSCOPE, VIROLOGY 17: 480 (1962).","journal-title":"VIROLOGY"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4049\/jimmunol.89.1.41","volume":"89","year":"1962","unstructured":"WALLIS, C, EFFECT OF CATIONS ON THERMAL INACTIVATION OF VACCINIA, HERPES SIMPLEX, AND ADENOVIRUSES, JOURNAL OF IMMUNOLOGY 89: 41 (1962).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_16_1","first-page":"683","volume":"19","year":"1961","unstructured":"WALLIS, C, STABILIZATION OF POLIOVIRUS BY CATIONS, TEXAS REPORTS ON BIOLOGY AND MEDICINE 19: 683 (1961).","journal-title":"TEXAS REPORTS ON BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_17_1","first-page":"700","volume":"19","year":"1961","unstructured":"WALLIS, C, TEXAS REPORTS ON BIOLOGY AND MEDICINE 19: 700 (1961).","journal-title":"TEXAS REPORTS ON BIOLOGY AND MEDICINE"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.156.3773.392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T08:02:34Z","timestamp":1704960154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.156.3773.392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,4,21]]},"references-count":17,"journal-issue":{"issue":"3773","published-print":{"date-parts":[[1967,4,21]]}},"alternative-id":["10.1126\/science.156.3773.392"],"URL":"https:\/\/doi.org\/10.1126\/science.156.3773.392","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,4,21]]}}}