{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T03:04:17Z","timestamp":1772247857817,"version":"3.50.1"},"reference-count":5,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3777","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1967,5,19]]},"abstract":"<jats:p>Intraperitoneal injection of physostigmine in rats produced a retrograde amnesia of a trained task of escaping shock. This amnesic effect was a U-shaped function of the length of the interval between initial training and injection. In all cases, retraining occurred 30 minutes after injection. A substantial effect was produced by physostigmine if its application was made 30 minutes after training; there was no effect if application and tests were made 1, 2, or 3 days after the original training. When the substance was injected and the rats were retrained 5, 7, or 14 days after the original training, a substantial effect again appeared. These results are similar to those reported in experiments in which another anticholinesterase, diisopropyl fluorophosphate, was applied intracerebrally. The data demonstrate a similar pattern of change of the amnesia with time, and they substantiate the view that neither the place of application nor the brain lesions caused the reported amnesia.<\/jats:p>","DOI":"10.1126\/science.156.3777.973","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T11:08:12Z","timestamp":1160046492000},"page":"973-974","source":"Crossref","is-referenced-by-count":61,"title":["Retrograde Amnesia Produced by Intraperitoneal Injection of Physostigmine"],"prefix":"10.1126","volume":"156","author":[{"given":"Martin D.","family":"Hamburg","sequence":"first","affiliation":[{"name":"Brain Research Laboratory, Department of Psychology, University of Michigan, Ann Arbor"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.ph.24.030162.001355","volume":"24","year":"1962","unstructured":"DEUTCH, J, HIGHER NERVOUS FUNCTION - PHYSIOLOGICAL BASES OF MEMORY, ANNUAL REVIEW OF PHYSIOLOGY 24: 259 (1962).","journal-title":"ANNUAL REVIEW OF PHYSIOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.151.3707.221"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.153.3739.1017"},{"key":"e_1_2_1_4_1","unstructured":"Olds J. 18th International Congress of Psychology (1966)."},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1152\/ajplegacy.1963.205.4.745","volume":"205","year":"1963","unstructured":"STARK, P, EFFECTS OF CHOLINERGIC DRUGS ON HYPOTHALAMIC SELF-STIMULATION RESPONSE RATES OF DOGS, AMERICAN JOURNAL OF PHYSIOLOGY 205: 745 (1963).","journal-title":"AMERICAN JOURNAL OF PHYSIOLOGY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.156.3777.973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T10:19:52Z","timestamp":1704968392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.156.3777.973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,5,19]]},"references-count":5,"journal-issue":{"issue":"3777","published-print":{"date-parts":[[1967,5,19]]}},"alternative-id":["10.1126\/science.156.3777.973"],"URL":"https:\/\/doi.org\/10.1126\/science.156.3777.973","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,5,19]]}}}