{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:05:39Z","timestamp":1762067139365},"reference-count":12,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3778","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1967,5,26]]},"abstract":"<jats:p>The excretion of oxypurine metabolites in urine of patients with congenital hyperuricosuria exceeds, on a creatinine basis, that observed in any previously recognized metabolic anomaly. The ratio of hypoxanthine to xanthine is from 2:1 to 3:1 and results from increased hypoxanthine excretion, in contrast to other hyperuricosuric conditions where ratios of less than one have been reported. Administration of allopurinol (a xanthine-oxidase inhibitor) reduces the excretion of uric acid but results in an equivalent increase in xanthine and hypoxanthine. These features appear to be unique to congenital hyperuricosuria.<\/jats:p>","DOI":"10.1126\/science.156.3778.1122","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T11:08:12Z","timestamp":1160046492000},"page":"1122-1123","source":"Crossref","is-referenced-by-count":49,"title":["Urinary Metabolites in Congenital Hyperuricosuria"],"prefix":"10.1126","volume":"156","author":[{"given":"M. Earl","family":"Balis","sequence":"first","affiliation":[{"name":"Sloan-Kettering Institute for Cancer Research, and Pediatrics Department, New York University School of Medicine, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin H.","family":"Krakoff","sequence":"additional","affiliation":[{"name":"Sloan-Kettering Institute for Cancer Research, and Pediatrics Department, New York University School of Medicine, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Berman","sequence":"additional","affiliation":[{"name":"Sloan-Kettering Institute for Cancer Research, and Pediatrics Department, New York University School of Medicine, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Dancis","sequence":"additional","affiliation":[{"name":"Sloan-Kettering Institute for Cancer Research, and Pediatrics Department, New York University School of Medicine, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1172\/JCI105231","volume":"44","year":"1965","unstructured":"AYVAZIAN, J.H., STUDY OF PURINE UTILIZATION AND EXCRETION IN XANTHINURIC MAN, JOURNAL OF CLINICAL INVESTIGATION 44: 1248 (1965).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_2_1","first-page":"341","year":"1955","unstructured":"Brown, G. B., The Nucleic Acids: 341 (1955).","journal-title":"The Nucleic Acids"},{"key":"e_1_2_1_3_1","unstructured":"ELION G PERSONAL COMMUNICATION."},{"key":"e_1_2_1_4_1","first-page":"305","volume":"4","year":"1964","unstructured":"Elion, G. B., Abstract. 6th International Congress on Biochemistry 4: 305 (1964).","journal-title":"Abstract. 6th International Congress on Biochemistry"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/ard.25.Suppl_6.651","volume":"25","year":"1966","unstructured":"Krakoff, I. H., Annals of the Rheumatic Diseases 25: 651 (1966).","journal-title":"Annals of the Rheumatic Diseases"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(64)90104-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/S0021-9258(18)91353-0","volume":"239","year":"1964","unstructured":"MCCOLLISTER, R.J., PSEUDOFEEDBACK INHIBITION OF PURINE SYNTHESIS BY 6-MERCAPTOPURINE RIBONUCLEOTIDE + OTHER PURINE ANALOGUES, JOURNAL OF BIOLOGICAL CHEMISTRY 239: 1560 (1964).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_8_1","first-page":"225","volume":"198","year":"1966","unstructured":"NEWCOMBE, D.S., JAMA 198: 225 (1966).","journal-title":"JAMA"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0021-9258(18)97657-X","volume":"240","year":"1965","unstructured":"NIERLICH, D.P., REGULATION OF PURINE RIBONUCLEOTIDE SYNTHESIS BY END PRODUCT INHIBITION - EFFECT OF ADENINE AND GUANINE RIBONUCLEOTIDES ON 5]-PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE OF AEROBACTER AEROGENES, JOURNAL OF BIOLOGICAL CHEMISTRY 240: 358 (1965).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_10_1","unstructured":"NYHAN W.L. UNPUBLISHED."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.155.3770.1682"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0002-9343(64)90131-7","volume":"37","year":"1964","unstructured":"YU, T. F., AMERICAN JOURNAL OF MEDICINE 37: 885 (1964).","journal-title":"AMERICAN JOURNAL OF MEDICINE"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.156.3778.1122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T08:01:30Z","timestamp":1704960090000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.156.3778.1122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,5,26]]},"references-count":12,"journal-issue":{"issue":"3778","published-print":{"date-parts":[[1967,5,26]]}},"alternative-id":["10.1126\/science.156.3778.1122"],"URL":"https:\/\/doi.org\/10.1126\/science.156.3778.1122","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,5,26]]}}}