{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T22:23:57Z","timestamp":1759703037156},"reference-count":19,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3786","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1967,7,21]]},"abstract":"<jats:p>\n            Adult Lewis rats were thymectomized, irradiated, and restored with bone marrow from allogeneic (or F\n            <jats:sub>1<\/jats:sub>\n            ) donors. They were passively sensitized to tuberculin by a subsequent transfer of Lewis lymph node cells and were given intradermal skin tests with tuberculoprotein. In 24-hour skin reactions the majority of cells, in successive experiments, were shown to be allogeneic (or F\n            <jats:sub>1<\/jats:sub>\n            ) with the use of isoantibody against the antigens of the transplanted marrow cells and by the indirect fluorescent antibody technique. Our results demonstrate that the nonspecific cells making up a large proportion of the infiltrating elements in tuberculin skin reactions probably originate in the bone marrow.\n          <\/jats:p>","DOI":"10.1126\/science.157.3786.322","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T11:08:12Z","timestamp":1160046492000},"page":"322-323","source":"Crossref","is-referenced-by-count":40,"title":["Delayed Hypersensitivity: Bone Marrow as the Source of Cells in Delayed Skin Reactions"],"prefix":"10.1126","volume":"157","author":[{"given":"David M.","family":"Lubaroff","sequence":"first","affiliation":[{"name":"Department of Microbiology, Yale University, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron H.","family":"Waksman","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Yale University, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4049\/jimmunol.98.2.269","volume":"98","year":"1967","unstructured":"COHEN, S, STUDIES ON SPECIFICITY OF CELLULAR INFILTRATE OF DELAYED HYPERSENSITIVITY REACTIONS, JOURNAL OF IMMUNOLOGY 98: 269 (1967).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1749-6632.1966.tb12858.x","volume":"129","year":"1966","unstructured":"DAVIES, AJS, ANN NY ACAD SCI 129: 274 (1966).","journal-title":"ANN NY ACAD SCI"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/00007890-196607000-00008","volume":"4","year":"1966","unstructured":"DAVIES, AJS, TRANSPLANTATION 4: 438 (1966).","journal-title":"TRANSPLANTATION"},{"key":"e_1_2_1_4_1","first-page":"516","volume":"32","year":"1951","unstructured":"GELL, PGH, THE HISTOLOGY OF THE TUBERCULIN REACTION AND ITS MODIFICATION BY CORTISONE, BRITISH JOURNAL OF EXPERIMENTAL PATHOLOGY 32: 516 (1951).","journal-title":"BRITISH JOURNAL OF EXPERIMENTAL PATHOLOGY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/196651a0","volume":"196","year":"1962","unstructured":"GOWANS, J.L., INITIATION OF IMMUNE RESPONSES BY SMALL LYMPHOCYTES, NATURE 196: 651 (1962).","journal-title":"NATURE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/201884a0","volume":"201","year":"1964","unstructured":"HARRIS, J.E., EVIDENCE THAT THYMUS PLAYS INSTRUCTIONAL PART, NATURE 201: 884 (1964).","journal-title":"NATURE"},{"key":"e_1_2_1_7_1","first-page":"8","year":"1963","unstructured":"Humphrey, J. 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