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Normal individuals suffer higher mortality rates and lower fertility rates in a malarious environment than individuals with the sickle-cell trait do, so the latter contribute proportionately more people to succeeding generations.<\/jats:p>","DOI":"10.1126\/science.157.3793.1134","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T11:08:12Z","timestamp":1160046492000},"page":"1134-1140","source":"Crossref","is-referenced-by-count":103,"title":["Sickle-Cell Trait in Human Biological and Cultural Evolution"],"prefix":"10.1126","volume":"157","author":[{"given":"Stephen L.","family":"Wiesenfeld","sequence":"first","affiliation":[{"name":"University of California San Francisco Medical Center, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1525\/aa.1966.68.1.02a00040","volume":"68","year":"1966","unstructured":"ALLAND, A, MEDICAL ANTHROPOLOGY AND STUDY OF BIOLOGICAL AND CULTURAL ADAPTATION, AMERICAN ANTHROPOLOGIST 68: 40 (1966).","journal-title":"AMERICAN ANTHROPOLOGIST"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1469-1809.1971.tb00266.x","volume":"21","year":"1956","unstructured":"ALLISON, A.C., THE SICKLE-CELL AND HAEMOGLOBIN-C GENES IN SOME AFRICAN POPULATIONS, ANNALS OF HUMAN GENETICS 21: 67 (1956).","journal-title":"ANNALS OF HUMAN GENETICS"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1749-6632.1961.tb31102.x","volume":"91","year":"1961","unstructured":"ALLISON, A.C., GENETIC FACTORS IN RESISTANCE TO MALARIA, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 91: 710 (1961).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1136\/bmj.1.4857.290","volume":"1","year":"1954","unstructured":"ALLISON, A. 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