{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:09:04Z","timestamp":1769688544869,"version":"3.49.0"},"reference-count":4,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3801","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1967,11,3]]},"abstract":"<jats:p>We have assessed the effects in normal control volunteers of 2,5-dimethoxy-4-methyl-amphetamine, the chemical present in the hallucinogenic drug STP, in two independent trials. In low doses, this compound produces a mild euphoria. Doses greater than 3 milligrams may cause pronounced hallucinogenic effects lasting about 8 hours and similar to those produced by hallucinogenic doses of lysergic acid diethylamide, mescaline, and psilocybin. 2,5-Dimethoxy-4-methyl-amphetamine, which is chemically related to mescaline and amphetamine, is about 100 times more potent as a hallucinogen than mescaline and only one-thirtieth as potent as lysergic acid diethylamide. Its psychological effects are not accentuated by chlorpromazine.<\/jats:p>","DOI":"10.1126\/science.158.3801.669","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T11:08:12Z","timestamp":1160046492000},"page":"669-670","source":"Crossref","is-referenced-by-count":119,"title":["2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug"],"prefix":"10.1126","volume":"158","author":[{"given":"Solomon H.","family":"Snyder","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Faillace","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Hollister","sequence":"additional","affiliation":[{"name":"Veterans Administration Hospital, Palo Alto, California 94304"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/cpt196455611","volume":"5","year":"1964","unstructured":"AGHAJANIAN, G.K., PERSISTENCE OF LYSERGIC ACID DIETHYLAMIDE IN PLASMA OF HUMAN SUBJECTS, CLINICAL PHARMACOLOGY & THERAPEUTICS 5: 611 (1964).","journal-title":"CLINICAL PHARMACOLOGY & THERAPEUTICS"},{"key":"e_1_2_1_2_1","unstructured":"JOFFE M PERSONAL COMMUNICATION."},{"key":"e_1_2_1_3_1","unstructured":"Snyder S. in preparation."},{"key":"e_1_2_1_4_1","unstructured":"Weingartner H. in preparation."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.158.3801.669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T08:21:47Z","timestamp":1704961307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.158.3801.669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,11,3]]},"references-count":4,"journal-issue":{"issue":"3801","published-print":{"date-parts":[[1967,11,3]]}},"alternative-id":["10.1126\/science.158.3801.669"],"URL":"https:\/\/doi.org\/10.1126\/science.158.3801.669","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,11,3]]}}}