{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:52:22Z","timestamp":1790887942244,"version":"4.1.0"},"reference-count":16,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3807","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1967,12,15]]},"abstract":"<jats:p>Intranuclear and intracytoplasmic aggregates of filaments with tubular structures and transverse striations occurred in muscle tissues biopsied from a patient with chronic polymyositis. The filamentous tubules bear a close resemblance to the incomplete form of myxovirus in which the envelope is missing. Three biopsies from the same patient, taken during a period of 1\u00bd years, all revealed these structures. This finding provides presumptive evidence that a chronic persistent viral infection may be involved in the pathogenesis of chronic polymyositis.<\/jats:p>","DOI":"10.1126\/science.158.3807.1453","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T11:08:12Z","timestamp":1160046492000},"page":"1453-1455","source":"Crossref","is-referenced-by-count":158,"title":["Myxovirus-Like Structures in a Case of Human Chronic Polymyositis"],"prefix":"10.1126","volume":"158","author":[{"given":"Shi-ming","family":"Chou","sequence":"first","affiliation":[{"name":"Department of Pathology and Regional Primate Research Center, University of Wisconsin Medical School, Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"31","volume":"6","year":"1967","unstructured":"ANE, C, ETUDE AU MICROSCOPE ELECTRONIQUE DE LA MORPHOGENESE DUN MYXOVIRUS PARAINFLUENZAE 3, JOURNAL OF MICROSCOPY-OXFORD 6: 31 (1967).","journal-title":"JOURNAL OF MICROSCOPY-OXFORD"},{"key":"e_1_2_1_2_1","first-page":"309","volume":"17","year":"1967","unstructured":"CHOU, S, MEGACONIAL MITOCHONDRIA OBSERVED IN A CASE OF CHRONIC POLYMYOSITIS, NEUROLOGY 17: 309 (1967).","journal-title":"NEUROLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0042-6822(66)90119-X","volume":"30","year":"1966","unstructured":"COMPANS, R.W., AN ELECTRON MICROSCOPIC STUDY OF MODERATE AND VIRULENT VIRUS-CELL INTERACTIONS OF PARAINFLUENZA VIRUS SV5, VIROLOGY 30: 411 (1966).","journal-title":"VIROLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.108.2794.61"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1128\/jvi.1.1.215-237.1967","volume":"1","year":"1967","unstructured":"HOWE, C, J VIROL 1: 215 (1967).","journal-title":"J VIROL"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1083\/jcb.6.3.379","volume":"6","year":"1959","unstructured":"KALLMAN, F, FINE STRUCTURE OF CELLULAR INCLUSIONS IN MEASLES VIRUS INFECTIONS, JOURNAL OF BIOPHYSICAL AND BIOCHEMICAL CYTOLOGY 6: 379 (1959).","journal-title":"JOURNAL OF BIOPHYSICAL AND BIOCHEMICAL CYTOLOGY"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/14.2.187","volume":"14","year":"1966","unstructured":"KASTEN, F.H., CYTOCHEMISTRY OF CYTOPLASMIC AND INTRANULCEAR INCLUSIONS INDUCED BY BOVINE PARAINFLUENZA 3 VIRUS (SF-4) IN HUMAN CELL CULTURES, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 14: 187 (1966).","journal-title":"JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.156.3782.1628"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev.me.17.020166.000431","volume":"17","year":"1966","unstructured":"PEARSON, C.M., POLYMYOSITIS, ANNUAL REVIEW OF MEDICINE 17: 63 (1966).","journal-title":"ANNUAL REVIEW OF MEDICINE"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/00005072-196707000-00009","volume":"26","year":"1967","unstructured":"PRICE, H.M., MYOPHATHY WITH ATYPICAL MITOCHONDRIA IN TYPE I SKELETAL MUSCLE FIBERS - A HISTOCHEMICAL AND ULTRASTRUCTURAL STUDY, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 26: 475 (1967).","journal-title":"JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1749-6632.1962.tb18898.x","volume":"101","year":"1962","unstructured":"REISINGER, R.C., PARAINFLUENZA 3 VIRUS IN CATTLE, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 101: 576 (1962).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/brain\/89.1.133","volume":"89","year":"1966","unstructured":"SHY, G.M., 2 CHILDHOOD MYOPATHIES WITH ABNORMAL MITOCHONDRIA .I. MEGACONIAL MYOPATHY .2. PLEOCONIAL MYOPATHY, BRAIN 89: 133 (1966).","journal-title":"BRAIN"},{"key":"e_1_2_1_13_1","first-page":"322","volume":"25","year":"1965","unstructured":"TAWARA, J, FINE STRUCTURE OF FILAMENTS IN DOG KIDNEY CELL CULTURES INFECTED WITH MEASLES VIRUS, VIROLOGY 25: 322 (1965).","journal-title":"VIROLOGY"},{"key":"e_1_2_1_14_1","first-page":"305","year":"1964","unstructured":"Walton, J. N., Disorders of Voluntary Muscle: 305 (1964).","journal-title":"Disorders of Voluntary Muscle"},{"key":"e_1_2_1_15_1","unstructured":"Walton J. N. Polymyositis (1958)."},{"key":"e_1_2_1_16_1","first-page":"190","volume":"78","year":"1952","unstructured":"ZWEYMULLER, V. E., DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT 78: 190 (1952).","journal-title":"DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.158.3807.1453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T08:18:54Z","timestamp":1704961134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.158.3807.1453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,12,15]]},"references-count":16,"journal-issue":{"issue":"3807","published-print":{"date-parts":[[1967,12,15]]}},"alternative-id":["10.1126\/science.158.3807.1453"],"URL":"https:\/\/doi.org\/10.1126\/science.158.3807.1453","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,12,15]]}}}