{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:08:54Z","timestamp":1767665334194},"reference-count":33,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3821","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1968,3,22]]},"abstract":"<jats:p>Activity of creatine kinase and aldolase in serum increased in 14 of 16 patients with recent onset of a psychotic reaction, and in five of six patients treated with psychotomimetic drugs. There was either no increase of these enzymes or a slight increase in severely agitated (or depressed) non-psychotic hospitalized patients and chronic psychotic patients. The increase of the enzymes preceded the onset of the acute psychotic symptoms in at least three cases, was highest during the first 2 weeks of a psychotic episode, and sometimes recurred throughout the illness, particularly at times of stress. The creatine kinase in the serum is primarily of the muscle type.<\/jats:p>","DOI":"10.1126\/science.159.3821.1368","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T11:50:27Z","timestamp":1160049027000},"page":"1368-1370","source":"Crossref","is-referenced-by-count":72,"title":["Creatine Kinase and Aldolase in Serum: Abnormality Common to Acute Psychoses"],"prefix":"10.1126","volume":"159","author":[{"given":"Herbert","family":"Meltzer","sequence":"first","affiliation":[{"name":"National Institute of Mental Health, Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"1306","volume":"1","year":"1965","unstructured":"ACHESON, J, SERUM-CREATINE-KINASE LEVELS IN CEREBRAL VASCULAR DISEASE, LANCET 1: 1306 (1965).","journal-title":"LANCET"},{"key":"e_1_2_1_2_1","first-page":"1272","volume":"2","year":"1966","unstructured":"AHLBORG, B, LANCET 2: 1272 (1966).","journal-title":"LANCET"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1212\/WNL.17.11.1073","volume":"17","year":"1967","unstructured":"BELTON, N.R., SERUM CREATINE PHOSPHOKINASE ACTIVITY IN EPILEPSY - CLINICAL AND EXPERIMENTAL STUDIES, NEUROLOGY 17: 1073 (1967).","journal-title":"NEUROLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005053-196610000-00008","volume":"143","year":"1966","unstructured":"BENGZON, A, SOME CHANGES IN SERUM DURING TREATMENT WITH PSYCHOTROPIC DRUGS, JOURNAL OF NERVOUS AND MENTAL DISEASE 143: 369 (1966).","journal-title":"JOURNAL OF NERVOUS AND MENTAL DISEASE"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.144.3616.311"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1001\/archneur.1967.00470190093011","volume":"16","year":"1967","unstructured":"BRODY, I.A., ORIGIN OF INCREASED SERUM CREATINE PHOSPHOKINASE IN TETANUS, ARCHIVES OF NEUROLOGY 16: 89 (1967).","journal-title":"ARCHIVES OF NEUROLOGY"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1113\/jphysiol.1957.sp005737","volume":"135","year":"1957","unstructured":"BROOKS, V.B., THE ACTION OF TETANUS TOXIN ON THE INHIBITION OF MOTONEURONES, JOURNAL OF PHYSIOLOGY-LONDON 135: 655 (1957).","journal-title":"JOURNAL OF PHYSIOLOGY-LONDON"},{"key":"e_1_2_1_8_1","first-page":"156","volume":"325","year":"1954","unstructured":"BRUNS, F, *BESTIMMUNG UND EIGENSCHAFTEN DER SERUMALDOLASE, BIOCHEMISCHE ZEITSCHRIFT 325: 156 (1954).","journal-title":"BIOCHEMISCHE ZEITSCHRIFT"},{"key":"e_1_2_1_9_1","first-page":"C6","volume":"21","year":"1963","unstructured":"BURGER, A, ISOENZYME DER KREATINKINASE, HELVETICA PHYSIOLOGICA ET PHARMACOLOGICA ACTA 21: C6 (1963).","journal-title":"HELVETICA PHYSIOLOGICA ET PHARMACOLOGICA ACTA"},{"key":"e_1_2_1_10_1","first-page":"321","volume":"14","year":"1965","unstructured":"DAWSON, D, ARCH NEUROL 14: 321 (1965).","journal-title":"ARCH NEUROL"},{"key":"e_1_2_1_11_1","first-page":"384","volume":"5","year":"1960","unstructured":"DREYFUS, J.C., ETUDE DE LA CREATINE-KINASE SERIQUE CHEZ LES MYOPATHES ET LEURS FAMILLES, REVUE FRANCAISE D ETUDES CLINIQUES ET BIOLOGIQUES 5: 384 (1960).","journal-title":"REVUE FRANCAISE D ETUDES CLINIQUES ET BIOLOGIQUES"},{"key":"e_1_2_1_12_1","first-page":"743","volume":"2","year":"1967","unstructured":"DUBO, H, SERUM-CREATINE-KINASE IN CASES OF STROKE HEAD INJURY AND MENINGITIS, LANCET 2: 743 (1967).","journal-title":"LANCET"},{"key":"e_1_2_1_13_1","first-page":"103","volume":"46","year":"1959","unstructured":"EBASHI, S, HIGH CREATINE PHOSPHOKINASE ACTIVITY OF SERA OF PROGRESSIVE MUSCULAR DYSTROPHY, JOURNAL OF BIOCHEMISTRY 46: 103 (1959).","journal-title":"JOURNAL OF BIOCHEMISTRY"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/brain\/80.4.557","volume":"80","year":"1957","unstructured":"EVANS, J.H., SERUM ALDOLASE AND THE DIAGNOSIS OF MYOPATHY, BRAIN 80: 557 (1957).","journal-title":"BRAIN"},{"key":"e_1_2_1_15_1","first-page":"415","volume":"17","year":"1963","unstructured":"GAUTIER, E, HELVETICA PAEDIATRICA ACTA 17: 415 (1963).","journal-title":"HELVETICA PAEDIATRICA ACTA"},{"key":"e_1_2_1_16_1","unstructured":"GERBER L UNPUBLISHED DATA."},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1210\/jcem-25-6-723","volume":"25","year":"1965","unstructured":"GRAIG, F.A., SERUM CREATINE PHOSPHOKINASE ACTIVITY IN ALTERED THYROID STATES, JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 25: 723 (1965).","journal-title":"JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0009-8981(66)90230-0","volume":"13","year":"1966","unstructured":"GRIFFITHS, P.D., SERUM LEVELS OF ATP - CREATINE PHOSPHOTRANSFERASE (CREATINE KINASE) . NORMAL RANGE AND EFFECT OF MUSCULAR ACTIVITY, CLINICA CHIMICA ACTA 13: 413 (1966).","journal-title":"CLINICA CHIMICA ACTA"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/193942a0","volume":"193","year":"1962","unstructured":"HALONEN, P.I., EFFECT OF PHYSICAL EXERCISE ON SOME ENZYMES IN SERUM, NATURE 193: 942 (1962).","journal-title":"NATURE"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0009-8981(62)90137-7","volume":"7","year":"1962","unstructured":"HUGHES, B.P., A METHOD FOR ESTIMATION OF SERUM CREATINE KINASE AND ITS USE IN COMPARING CREATINE KINASE AND ALDOLASE ACTIVITY IN NORMAL AND PATHOLOGICAL SERA, CLINICA CHIMICA ACTA 7: 597 (1962).","journal-title":"CLINICA CHIMICA ACTA"},{"key":"e_1_2_1_21_1","first-page":"498","volume":"2","year":"1963","unstructured":"LEHMANN, H, CREATINE-PHOSPHOKINASE ACTIVITY IN SEMEN, LANCET 2: 498 (1963).","journal-title":"LANCET"},{"key":"e_1_2_1_22_1","first-page":"505","volume":"2","year":"1964","unstructured":"MULLAN, D.M., SERUM ENZYMES IN DIAGNOSIS OF TETANUS, LANCET 2: 505 (1964).","journal-title":"LANCET"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.0954-6820.1966.tb07980.x","volume":"179","year":"1966","unstructured":"NYGREN, A, SERUM CREATINE PHOSPHOKINASE ACTIVITY IN CHRONIC ALCOHOLISM IN CONNECTION WITH ACUTE ALCOHOL INTOXICATION, ACTA MEDICA SCANDINAVICA 179: 623 (1966).","journal-title":"ACTA MEDICA SCANDINAVICA"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0009-8981(63)90155-4","volume":"8","year":"1963","unstructured":"RICHTERICH, R, A STUDY OF LACTIC DEHYDROGENASE ISOENZYME PATTERN OF HUMAN TISSUES BY ADSORPTION-ELUTION ON SEPHADEX-DEAE, CLINICA CHIMICA ACTA 8: 178 (1963).","journal-title":"CLINICA CHIMICA ACTA"},{"key":"e_1_2_1_25_1","first-page":"696","volume":"69","year":"1967","unstructured":"ROSALKI, S.B., AN IMPROVED PROCEDURE FOR SERUM CREATINE PHOSPHOKINASE DETERMINATION, JOURNAL OF LABORATORY AND CLINICAL MEDICINE 69: 696 (1967).","journal-title":"JOURNAL OF LABORATORY AND CLINICAL MEDICINE"},{"key":"e_1_2_1_26_1","first-page":"1997","volume":"148","year":"1954","unstructured":"SCHAPIRA, F, *HYPERALDOLASEMIE PLASMATIQUE PROVOQUEE PAR LA CORTISONE ET LACTH, COMPTES RENDUS DES SEANCES DE LA SOCIETE DE BIOLOGIE ET DE SES FILIALES 148: 1997 (1954).","journal-title":"COMPTES RENDUS DES SEANCES DE LA SOCIETE DE BIOLOGIE ET DE SES FILIALES"},{"key":"e_1_2_1_27_1","first-page":"78","year":"1963","unstructured":"Schapira, G., Muscular Dystrophy in Man and Animals: 78 (1963).","journal-title":"Muscular Dystrophy in Man and Animals"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.5694\/j.1326-5377.1965.tb19273.x","volume":"2","year":"1965","unstructured":"SCHIAVONE, D, MEDICAL JOURNAL OF AUSTRALIA 2: 790 (1965).","journal-title":"MEDICAL JOURNAL OF AUSTRALIA"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/00000441-196109000-00009","volume":"242","year":"1961","unstructured":"SCHLANG, H.A.,AMERICAN JOURNAL OF THE MEDICAL SCIENCES 242: 338 (1961).","journal-title":"AMERICAN JOURNAL OF THE MEDICAL SCIENCES"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1055\/s-0028-1111974","volume":"88","year":"1963","unstructured":"SCHNEIDER, K.W., DIE DIAGNOSTISCHE BEDEUTUNG EINER ERHOHTEN KREATIN-PHOSPHOKINASE-AKTIVITAT IM SERUM, DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT 88: 520 (1963).","journal-title":"DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1016\/S0021-9258(18)69649-8","volume":"234","year":"1959","unstructured":"TANZER, M.L., CREATINE AND CREATINE KINASE MEASUREMENT, JOURNAL OF BIOLOGICAL CHEMISTRY 234: 3201 (1959).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1136\/bmj.1.5451.1653","volume":"1","year":"1965","unstructured":"VEJJAJIVA, A, BRITISH MEDICAL JOURNAL 1: 1653 (1965).","journal-title":"BRITISH MEDICAL JOURNAL"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1749-6632.1958.tb36869.x","volume":"75","year":"1958","unstructured":"ZIERLER, K.L., MUSCLE MEMBRANE AS A DYNAMIC STRUCTURE AND ITS PERMEABILITY TO ALDOLASE, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 75: 227 (1958).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.159.3821.1368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T08:40:26Z","timestamp":1704962426000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.159.3821.1368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,3,22]]},"references-count":33,"journal-issue":{"issue":"3821","published-print":{"date-parts":[[1968,3,22]]}},"alternative-id":["10.1126\/science.159.3821.1368"],"URL":"https:\/\/doi.org\/10.1126\/science.159.3821.1368","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,3,22]]}}}