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The demonstration of two populations of clones, wild-type clones with normal enzyme activity and mutant clones unable to incorporate\n            <jats:sup>3<\/jats:sup>\n            H-guanine, is evidence that the locus for hypoxanthineguanine phosphoribosyl transferase on one of the X chromosomes is inactive.\n          <\/jats:p>","DOI":"10.1126\/science.160.3826.425","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T11:50:27Z","timestamp":1160049027000},"page":"425-427","source":"Crossref","is-referenced-by-count":138,"title":["X-Linked Hypoxanthine-Guanine Phosphoribosyl Transferase Deficiency: Heterozygote Has Two Clonal Populations"],"prefix":"10.1126","volume":"160","author":[{"given":"Barbara R.","family":"Migeon","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vazken M.","family":"Der Kaloustian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William L.","family":"Nyhan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barton","family":"Childs","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1084\/jem.126.3.509","volume":"126","year":"1967","unstructured":"DANES, B.S., HURLERS SYNDROME - 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